Thorax Traumas
Conditions
Keywords
thorax trauma, ROX index, Surfactant-d
Brief summary
This prospective study aimed to predict morbidity and mortality after thoracic trauma in intensive care unit evaluated clinical and biochemical data of 50 intensive care unit patients. The research examined demographic factors such as gender, age, and smoking status, trauma scoring systems like ISS and RTS as well as biomarkers such as Surfactant-d and oxygenation parameters including the ROX index, PaO₂/FiO₂ ratio and FiO₂.
Interventions
DIAGNOSTIC_TESTblood sampling
blood samples obtained for 3 different days, limited to 5cc
Sponsors
Suleyman Demirel University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Patients with thoracic trauma between the ages of 18-85 * Patients who have been monitored in intensive care for at least 1 week
Exclusion criteria
* Being outside the age range of 18-85 * Pregnant patients * Patients whose intensive care follow-up lasted less than 1 week * Patients who do not want to be included in the study * Patients with a lung malignancy diagnosis before admission
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mortality Prediction Using SP-D Levels in Thoracic Trauma Patients | Measurements taken on day 1, day 3, and day 7 of hospitalization, following ICU admission. | To assess the prognostic value of Surfactant Protein D (SP-D) levels (unit: ng/mL) for mortality prediction in thoracic trauma patients. SP-D levels were measured using an ELISA assay (Elabscience® Human Pulmonary Surfactant-associated Protein-D ELISA Kit) at 1st, 3rd, and 7th days to evaluate trends and correlations with survival outcomes. |
| Mortality Prediction Using ROX Index in Thoracic Trauma Patients | Measurements taken on day 1, day 3, and day 7 of hospitalization, following ICU admission. | To evaluate the predictive ability of the ROX index (unit: cmH₂O/L/s) for mortality in thoracic trauma patients. ROX index values were recorded at 1st, 3rd, and 7th days of hospitalization using standard clinical monitoring and ventilatory support parameters. Trends were analyzed in relation to survival outcomes. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Predictive Value of SOFA Score in Mortality | Measurements taken on day 1, day 3, and day 7 of hospitalization. | To evaluate the prognostic accuracy of the Sequential Organ Failure Assessment (SOFA) score (range: 0-24; higher scores indicate worse outcomes) in thoracic trauma patients. SOFA scores were determined based on respiratory, cardiovascular, hepatic, coagulation, renal, and neurological functions at 1st, 3rd, and 7th days. |
| Predictive Value of TRISS Score in Mortality | Measurements taken on day 1, day 3, and day 7 of hospitalization. | To examine the relationship between Trauma and Injury Severity Score (TRISS) (range: 0-100%; higher scores indicate better survival probability) and survival outcomes in thoracic trauma patients. TRISS scores were calculated using physiological and anatomical injury severity data at 1st, 3rd, and 7th days. |
| CRP Levels and Mortality Prediction | Measurements taken on day 1, day 3, and day 7 of hospitalization. | To evaluate the association between C-reactive protein (CRP) levels (unit: mg/L) and mortality in thoracic trauma patients. |
| Procalcitonin Levels and Mortality Prediction | Measurements taken on day 1, day 3, and day 7 of hospitalization. | To analyze the prognostic value of procalcitonin (unit: ng/mL) levels in mortality prediction among thoracic trauma patients. |
| Predictive Value of RTS Score in Mortality | Measurements taken on day 1, day 3, and day 7 of hospitalization. | To assess the relationship between Revised Trauma Score (RTS) (range: 0-7.84; higher scores indicate better prognosis) and mortality risk in thoracic trauma patients. RTS scores were calculated using Glasgow Coma Scale, systolic blood pressure, and respiratory rate values at 1st, 3rd, and 7th days. |
| Predictive Value of APACHE II Score in Mortality | Measurements taken on day 1, day 3, and day 7 of hospitalization. | To analyze the effectiveness of the APACHE II score (range: 0-71; higher scores indicate worse outcomes) in predicting mortality in thoracic trauma patients. APACHE II scores were calculated based on clinical and laboratory parameters, including vital signs, blood gas values, and organ dysfunction markers at 1st, 3rd, and 7th days. |
Other
| Measure | Time frame | Description |
|---|---|---|
| NEU/LYM Ratio and Mortality Correlation | Measurements taken on day 1, day 3, and day 7 of hospitalization. | To investigate the prognostic role of the Neutrophil-to-Lymphocyte Ratio (NEU/LYM) (unit: ratio value) in predicting mortality among thoracic trauma patients. NEU/LYM values were obtained from complete blood count (CBC) results and recorded at 1st, 3rd, and 7th days |
| Glasgow Coma Scale (GCS) and Mortality Correlation | Measurements taken on day 1, day 3, and day 7 of hospitalization. | Description: To evaluate the predictive value of the Glasgow Coma Scale (GCS) score on mortality and other clinical outcomes in thoracic trauma patients. Score Range: 3-15 (lower scores indicate worse outcomes). |
Countries
Turkey (Türkiye)
Outcome results
None listed