Acute Type A Aortic Dissection
Conditions
Keywords
Acute type A aortic dissection, Prolonged mechanical ventilation, mechanical ventilation time
Brief summary
The goal of this observational study is to develop and validate a predictive model for prolonged mechanical ventilation (PMV) following acute type A aortic dissection (ATAAD) surgery. The main questions it aims to answer are: 1. To validate the predictive performance of the model for PMV after ATAAD surgery 2. To assess the proportion of PMV among patients undergoing ATAAD surgery 3. To evaluate the ICU length of stay and operative mortality in patients with PMV following ATAAD surgery
Interventions
None listed
Sponsors
China-Japan Friendship Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
* Age ≥18 years; * Diagnosis of acute type A aortic dissection (ATAAD) confirmed by computed tomography angiography and echocardiography; * Patients who underwent aortic surgery requiring cardiopulmonary bypass (CPB), were admitted to the surgical intensive care unit (SICU), and received mechanical ventilation.
Exclusion criteria
* Reintubation; * Intraoperative death or failure to survive beyond 72 hours postoperatively; * Pregnancy; * Severe comorbidities (e.g., lung cancer); * Missing critical outcome data (e.g., short-term mortality, mechanical ventilation duration, reintubation).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The predictive performance of the model for prolonged mechanical ventilation (PMV) following acute type A aortic dissection (ATAAD) surgery | 72 hours after ATAAD surgery | The predictive performance of PMV following ATAAD surgery includes its discriminative ability and calibration ablility. |
| The proportion of patients with PMV | 72 hours after ATAAD surgery | The proportion of patients with PMV refers to the proportion of patients with PMV among the total included ATAAD postoperative patients. PMV is defined as postoperative mechanical ventilation lasting more than 72 hours |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| ICU length of stay (ICU-LOS) | From surgery to discharge or death, whichever came first, assessed up to 6 months | ICU length of stay was defined as the length of time spent in ICU from surgery to discharge or death. |
| surgery-related mortality | 30 days after ATAAD surgery | surgery-related mortality encompassed any death occurring during the index hospitalization (even beyond 30 days) or after discharge but before postoperative day 30. |
Countries
China
Contacts
Primary ContactZhou Xiaoming, Dr
Backup ContactZhang Qin, Dr
Outcome results
None listed