Parkinson Disease
Conditions
Keywords
Retinal oximetry, Pattern Electroretinography, Visual Evoked Potentials, Optical Coherence Tomography, Oxyhemoglobin saturation
Brief summary
The goal of this observational study is to determine whether oxygen content of the retinal vessels of the eye may serve as a biomarker in Parkinson´s disease. The main questions it aims to answer are: 1. Is retinal vessel oxyhemoglobin saturation and vessel width altered in people with Parkinson´s disease? 2. Is the thickness of the retinal nerve fiber layer altered in people with Parkinson´s disease? 3. Is the response of ganglion cells of the inner retina and the visual cortex altered in people with Parkinson´s disease? The study procedure is threefold. The participants will: A. Sit in front of a screen and focus on a red dot of its middle. A simple recording electrodes are applied on the cornea, forehead and scalp for the electrophysiological measurements. Prior to this procedure a topical anesthetic gel is applied to numb the eye to prevent discomfort from placement of the corneal electrodes. B. Undergo general eye examination and optical coherence tomography (OCT) to measure the retinal tissue thickness. Prior to eye examination,eye drops are applied into the eyes to enlarge the pupils C. Sit in front of a fundus camera for obtaining images of the retinal vessels to measure oxygen saturation and the vessel width Researchers will compare the obtained measurements with age- and gender matching of healthy controls.
Interventions
None listed
Sponsors
Reykjalundur Rehabilitation
University of Iceland
Landspitali University Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Confirmed Parkinson Disease
Exclusion criteria
* Eye disease * Diabetic Mellitus * Chronic Obstructive Pulmonary Disease (COPD) * Other Neurological Disease * Smoking on a daily basis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Retinal vessels oxyhemoglobin saturation | Baseline. On the visit to the ambulatory Opthalamic department at Landspitali | Obtained by retinal oximetry |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Vessel width of retinal arterioles and venules | Baseline. On the visit to the ambulatory Opthalamic department at Landspitali | Obtained by retinal oximetry |
| Retinal nerve fiber layer thickness | Baseline. On the visit to the ambulatory Opthalamic department at Landspitali | Obtained by cross-sectional imaging of the retinal tissue (OCT) |
| Components and waveform of VEPs | Baseline. On the visit to the ambulatory Opthalamic department at Landspitali | Pattern electroretinogram (PERG) |
| Pattern electroretinograms (PERGs) | Baseline. On the visit to the ambulatory Opthalamic department at Landspitali | Amplitude of the visual evoked potential response |
Countries
Iceland
Outcome results
None listed