Medium-term Results of the LPS™ System for Segmental Resection of the Distal Femur, a Multicenter Retrospective Study (RESIF)

Medium-term Results of the LPS™ System for Segmental Resection of the Distal Femur, a Multicenter Retrospective Study.

Status

Enrolling by invitation

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06928948

Acronym

RESIF

Enrollment

Registered

2025-04-15

Start date

2024-11-01

Completion date

2025-07-31

Last updated

2025-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prosthesis Failure

Keywords

megaprosthesis, knee replacement

Brief summary

The reconstruction of the distal femur using modular systems has become increasingly popular over the years, surpassing primary arthrodesis or amputation. Despite the significant advantages of using megaprostheses, complications are not uncommon. Although the Limb Preservation System™ (LPS™, DePuy Synthes; Warsaw, USA) is one of the most widely used megaprostheses in the French market, there is currently no national evaluation of this system, and only two studies have been conducted worldwide. The aim of our study is to present the mid-term survival rates of the LPS™ implant in order to answer three main questions: 1. What are the overall outcomes of the LPS™ system in distal femur replacement? 2. What factors are associated with a reduced survival rate of the implant? 3. What is the cumulative risk of complications according to Henderson's classification? The secondary objective is to analyze the occurrence of specific failures, providing insights for potential improvements in the design and use of the LPS™ implant.

Interventions

PROCEDUREFemur replacement

Reconstruction using the Limb Preservation System™ for segmental resection of the distal femur.

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

\- Patients who underwent distal femoral reconstruction using the LPS system.

Exclusion criteria

* Lost to follow-up before 3 months. * Associated tibial reconstruction using the LPS system. * Total femoral reconstruction using the LPS system.

Design outcomes

Primary

Measure	Time frame	Description
LPS stent failure	From enrollment to last consultation	Failure will be defined as the replacement of the femoral anchorage or amputation.

Secondary

Measure	Time frame	Description
complications of the LPS stent	From enrollment to last consultation	Complications will be defined according to Henderson's classification.
Surgical revision of the LPS stent	From enrollment to last consultation	Any reoperation on the knee after the LPS one

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026