Gout
Conditions
Brief summary
The most frequent crystal arthropathy is gout, which is also the most prevalent cause of inflammatory arthritis. Gouty Patients frequently have excruciating pain and swelling in their joints. Gout is linked to decreased health-related quality of life and functional disability. Gout and its associated diseases have been shown to have a significant impact on patients mortality and morbidities. Metformin, a biguanide, is used to manage diabetes by reducing insulin resistance and preventing comorbidities such as cerebrovascular and coronary artery disease, as well as providing renal protection to diabetic nephropathy patients
Interventions
OTHERplacebo
Placebo will have the same look of metformin
DRUGMetformin
Metformin, a biguanide, is used to manage diabetes by reducing insulin resistance and preventing comorbidities such as cerebrovascular and coronary artery disease, as well as providing renal protection to diabetic nephropathy patients
Sponsors
Mostafa Bahaa
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Masking description
Double blinded
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Gouty patients clinically diagnosed as gouty arthritis based on the American College of Rheumatology/European League Against Rheumatism criteria of gout.
Exclusion criteria
* Systemic disorders such as cardiovascular, neurological, coronary artery disease. * Hypertension, hyperlipidemia, diabetes mellitus, active infections. * Other inflammatory or autoimmune diseases. * Patients on biologics, * Cases with hypersensitivity to metformin and those with impaired liver and kidney functions.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| - Clinical assessment of disease activity | 3 months | \- Clinical assessment of disease activity by assessing patient and physician VAS visual analog scale (0-10 cm); |
Countries
Egypt
Outcome results
None listed