fMRI Research, Hepatic Encephalopathy (HE), MRI
Conditions
Keywords
Hepatic Encephalopathy, fMRI
Brief summary
This clinical trial study aims to detect the imaging characteristics of patients with hepatic encephalopathy (HE) using 7-Tesla (7T) magnetic resonance imaging (MRI).
Detailed description
In this study, we analyzed the imaging characteristics of HE. First, with the advantages of 7TMRI, we analyzed the differences in imaging characteristics between HE patients and the healthy, including brain functional imaging and structural imaging. Second, we analyzed the differences in imaging characteristics between different subgroups of HE patients. Finally, we analyzed the correlation between the prognostic results of HE patients after follow-up and the imaging characteristics.
Interventions
OTHER7.0T MRI-Scan
7.0T MRI-Scan
Sponsors
Chinese PLA General Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 89 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients with clinical suspected or diagnosed hepatic encephalopathy according to relevant guidelines.The patient's education level is above primary school level. * Regular follow-up.
Exclusion criteria
* Contraindications to MRI. * Patients with cerebrovascular disease, brain tumors, epilepsy, other neurodegenerative disease.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Functional connectivity and structural alterations between individuals with different subtypes of HE and healthy subjects. | 5 years | Functional connectivity calculation is mainly based on the BOLD sequence, which is used to describe the degree of connectivity between different brain regions and reflect the functional activity of the brain. Gray matter (GM) morphological destruction, cortical thickness, and subcortical nuclear volume in patients with hepatic encephalopathy were analyzed based on structural magnetic resonance imaging（sMRI）. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between spectral features of clinical variables and spectral features of imaging. | 5 years | The clinical variable spectrum characteristics were constructed using the patients' medical records and test data. The distribution characteristics of clinical psychological characteristics and imaging spectrum characteristics were compared using a multidimensional matrix, and gene-imaging association analysis was used to evaluate imaging changes. |
Countries
China
Contacts
Primary ContactJing Tang
Outcome results
None listed