Bronchiectasis, COPD, Idiopathic Pulmonary Fibrosis (IPF), Interstitial Pneumonia, Pulmonary Heart Disease, Pulmonary Hypertension, Pulmonary Tuberculosis, Respiratory Failure, Silicosis
Conditions
Keywords
lung transplantatipn, Perioperative-related risks, Mortality, In-hospital complications, Prognosis
Brief summary
This study analyzes patients who underwent lung transplantation at the First Affiliated Hospital of Zhejiang University from 2017 to 2024, focusing on anesthesia's impact on post-op results. It gathers patient data from hospital and Mediston systems, with main focus on in-hospital complications and secondary focus on ICU stay, post-op hospitalization, mortality, and intubation time. The research aims to deepen understanding of anesthetic management's role in lung transplant outcomes and guide improvements in perioperative anesthesia protocols.
Interventions
None listed
Sponsors
Zhejiang University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age \>18 years at time of transplantation * Received single or bilateral lung transplantation
Exclusion criteria
* Re-transplantation * Multi-organ transplantation * Autotransplantation * Incomplete medical records: Recipients with \>20% missing essential data elements in any of these categories:Preoperative baseline characteristics； Intraoperative parameters；Postoperative outcome measures
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| In-hospital adverse events | Collect data for an expected average about 2 hours | In-hospital adverse events were defined as post-transplant complications occurring prior to discharge, such as: Grade 3 PGD, respiratory infections, stroke, cardiac events, AKI, or liver impairment. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The duration of endotracheal intubation | Collect data for an expected average about 2 hours | Duration of intubation should be recorded from surgery end-time to extubation |
| ICU stay | Collect data for an expected average about 2 hours | The ICU stay （days） was calculated from the time of ICU admission after surgery completion to actual discharge from the intensive care unit |
| Postoperative hospital stay | Collect data for an expected average about 2 hours | Postoperative hospital（days）stay after lung transplantation |
| In-hospital mortality | Collect data for an expected average about 2 hours | The proportion of patients who died during the initial hospitalization period following lung transplantation surgery |
| 30-day postoperative mortality | Collect data for an expected average about 2 hours | Number of deaths within 30 days post-transplant) / (Total number of lung transplant recipients) × 100%； |
| 90-day postoperative mortality | Collect data for an expected average about 2 hours | Number of deaths within 90 days post-transplant) / (Total number of lung transplant recipients) × 100% |
Other
| Measure | Time frame | Description |
|---|---|---|
| Grade 3 Primary Graft Dysfunction (PGD) | Collect data for an expected average about 2 hours | PGD3:A ratio of arterial oxygen partial pressure to fraction of inspired oxygen (PaO₂/FiO₂) \< 200 mmHg with bilateral infiltrates on chest radiograph, or Requirement for extracorporeal life support (ECLS) within 72 hours postoperatively, or use of inhaled pulmonary vasodilators for \>48 hours during mechanical ventilation. |
| Pulmonary Infection | Collect data for an expected average about 2 hours | Radiologically confirmed by a staff radiologist as new or progressive pulmonary infiltrates on: Chest X-ray or Computed tomography (CT) scan |
| Acute Kidney Injury | Collect data for an expected average about 2 hours | A rise in serum creatinine \>120 μmol/L |
| Cardiovascular Events | Collect data for an expected average about 2 hours | Acute myocardial infarction； heart failure；Cardiovascular hemorrhage；Clinically significant arrhythmias；Conduction system disorders；Cardiac arrest；Refractory hypotension due to cardiogenic sock. |
| Hepatic Dysfunction | Collect data for an expected average about 2 hours | Aspartate aminotransferase (AST) \>34 or Alanine aminotransferase (ALT) \>40 U/L; |
| Cerebral Infarction | Collect data for an expected average about 2 hours | Diagnosed by staff radiologists as new or progressive ischemic lesions on CT or MRI |
Countries
China
Contacts
Primary ContactDiansan Su, Dr
Backup Contactchaoqin Chen, Dr
Outcome results
None listed