Pacemaker, Tricuspid Regurgitation
Conditions
Brief summary
Tricuspid regurgitation (TR) is a common complication following cardiac implantable electronic device (CIED) implantation, with severe TR being associated with increased rates of heart failure hospitalization and all-cause mortality, significantly impairing patients' quality of life. With technological advancements, physiological pacing modalities have demonstrated superior clinical efficacy and safety profiles compared to conventional pacing methods. This study aims to evaluate predictors of adverse outcomes and TR progression in CIED recipients under different pacing modalities, thereby providing clinical guidance for high-risk patients.
Detailed description
This retrospective study analyzed patients undergoing pacemaker implantation from January 2015 to March 2025, stratified by pacing modality (right ventricular/conduction system/biventricular pacing) and TR progression (worsened \[≥1-grade increase\] vs non-worsened TR). The protocol included: (1) 3D echocardiographic assessment of TR mechanisms, (2) quantitative fluoroscopic analysis of lead parameters (tension, mobility, angulation), (3) multivariable regression evaluating pacing modes and TR progression on clinical outcomes, and (4) documentation of device-related complications (lead dislodgement/infection) and heart failure rehospitalization.
Interventions
DEVICEPacemaker implantation
Pacemaker implantation methods include right ventricular pacing, biventricular pacing, conduction system pacing
Sponsors
Haiyan Wang
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Adult patients 2. Patients with an implantable electronic heart device (CIEDs) 3. The patient underwent pacemaker implantation at Qianfoshan Hospital between 2015 and 2025
Exclusion criteria
1. Patients with severe tricuspid regurgitation or those who have undergone tricuspid valve surgery or interventional treatment prior to pacemaker implantation 2. Patients with severe valvular heart disease, congenital heart disease, or arrhythmias 3. Patients with single-chamber pacemakers or poor images
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Tricuspid regurgitation progression（Progression of tricuspid regurgitation ≥ grade 0.5） | Mean follow-up of 1 year | Grading of tricuspid regurgitation severity:Grade 0: None Grade 0.5: Trace Grade 1: Mild Grade 1.5: Mild to moderate Grade 2: Moderate Grade 2.5: Moderate to severe Grade 3: Severe |
Secondary
| Measure | Time frame |
|---|---|
| Heart Failure Readmission Rate After CIED Implantation | Mean follow-up of 1 year |
Countries
China
Contacts
Primary ContactHaiyan Wang, MD
Outcome results
None listed