Retrospective Identification of Scintigraphic Cardiac Amyloidosis (RISCA)

Retrospective Identification of Scintigraphic Cardiac Amyloidosis Using Deep Learning-based Model

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06921408

Acronym

RISCA

Enrollment

Registered

2025-04-10

Start date

2026-09-01

Completion date

2027-12-01

Last updated

2026-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Amyloidosis, Transthyretin Amyloidosis

Keywords

Cardiac Amyloidosis, Bone Scintigraphy, Deep learning

Brief summary

This study aims to determine the positive predictive value of incidental cardiac uptake on bone scintigraphy for diagnosing transthyretin cardiac amyloidosis, in patients who underwent scintigraphy for reasons other than suspected amyloidosis. The study is an observational, descriptive, multicenter, national study using retrospective data from routine care. Patients with incidental cardiac uptake will be recalled for further diagnostic assessment.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Adults (≥ 18 years) * Patients who underwent bone scintigraphy with 99mTc-HMDP/DPD/PYP for any indication * Incidental cardiac uptake (Perugini grade ≥2) confirmed by a nuclear medicine specialist

Exclusion criteria

* Patients under legal protection * Patients refusing the reuse of their data after individual information

Design outcomes

Primary

Measure	Time frame
Cardiac amyloidosis diagnosis	After the reassessment evaluation (one-day evaluation)

Contacts

CONTACTMarc-Antoine DELBARRE

marcantoine.delbarre@gmail.com+33 3 20 44 59 69

Outcome results