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Study of Auditory Perception After Progressive Exposure to Aversive Sounds in People With Misophonia

Etude de la Perception Auditive après Exposition PROgressive Aux Sons Aversifs Chez Des Personnes MISophonEs

Status
Not yet recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06921187
Acronym
PROMISE
Enrollment
110
Registered
2025-04-10
Start date
2025-06-30
Completion date
2026-03-31
Last updated
2025-04-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Misophonia

Brief summary

The primary objective of the project is to characterise and measure the auditory perception of subjects with misophonia compared with the auditory perception of control subjects.

Interventions

BEHAVIORALPsychoacoustic test

Natural sounds will be presented at different decibels (dB), and the subject will be asked to rate the pleasantness/unpleasantness of the sound heard on a visual analogue scale, as well as the loudness (subjective intensity) of the sound heard.

OTHERsemi-structured interviews

interview, designed under the supervision of a psychologist and using the methodology of micro-phenomenological interviews the aim of these interviews is to gain access to the participants' experiences, as they describe them in the first person, during misophonic episodes

OTHERExposure to unpleasant sounds

Home exposure is a practice whereby participants voluntarily subject themselves to SMs in a controlled environment. Participants will be asked to complete two tasks: firstly, they will have to expose themselves to all 10 sounds at least twice a week; secondly, they will have to record the annoyance felt for each sound and the subjective loudness (loudness) of each SM using VAS.

Sponsors

Institut de l'Audition
CollaboratorOTHER
Institut Pasteur
Lead SponsorINDUSTRY

Study design

Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE

Intervention model description

exposure to unpleasant sounds at home is the focus of this study

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

For all participants * Obtain oral consent from the participant after receiving information about the study, * Be 18 years or older on the day of inclusion, * Be fluent in French (spoken and written), * Have no known hearing loss, verified by pure tone audiometry. * Declare that they do not have tinnitus, * Declare that they do not have hyperacusis, verified by measuring discomfort thresholds. * Be affiliated to the social security or equivalent scheme. For participants with misophonia: \- Declare discomfort, reduced tolerance to specific sounds (mouth noises, throat clearing, breathing, etc.).

Exclusion criteria

* Bear the after-effects of an ear infection and/or have a history of an ENT disease that permanently affects hearing or balance (vestibular schwannoma, Ménière's disease, sudden or fluctuating deafness, congenital hypoacusis), * Be under guardianship, * deprived of liberty by judicial or administrative decision, or subject to legal protection.

Design outcomes

Primary

MeasureTime frameDescription
score on a visual analogue scale from 0 (pleasant sound) to 10 (unpleasant sound)1 week after enrollmentsounds will be presented at different decibels and the subject will be asked to rate the pleasantness/unpleasantness of the sound on a visual analogue scale
score on a visual analogue scale from 0 (very low intensity) to 10 (extremely intense)1 week after enrollmentsounds will be presented at different decibels and the subject will be asked to rate the intensity of the sound on a visual analogue scale

Secondary

MeasureTime frameDescription
Measuring the consistency of the psychoacoustic test1 week after enrollementconsistency measured by calculating Cronbach's alpha coefficient
the number of redundant themes in the semi-structured interviews1 month after enrollmentthe interviews consist of open-ended questions covering different aspects of the experiences of misophone subjects
score on a visual analogue scale from 0 (very little discomfort) to 10 (extreme discomfort)1 month after enrollment and 2 months after enrollment

Countries

France

Contacts

Primary ContactArnaud Norena
arnaud.norena@univ-amu.fr+33488576863
Backup ContactPaul Avan
paul.avan@pasteur.fr

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026