This Present Study Can be Used by Clinicians Who Treat Psychiatric Patients: Dentists Might Expect Xerogenic Side Effects of Specific Psychiatric Drugs Which Can Affect Dental Treatment, and the Results Can Help Psychiatrist to Choose the Less Xerogenic Psychiatric Medication

Xerogenic Potential of the Most Frequently Prescribed Psychiatric Drugs

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06920472

Enrollment

361

Registered

2025-04-09

Start date

2013-01-01

Completion date

2018-01-01

Last updated

2025-05-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Psychiatric Disorders, Xerostomia Due to Hyposecretion of Salivary Gland

Brief summary

The goal of this observational study is to learn about the effects of psychiatric drug therapies on intra- and extra-oral sicca symptoms and salivation. The main question that it aims to answer is: Does taking psychiatric medication cause oral dryness and/or any changes on whole and minor saliva secretion? Participants taking psychiatric medication answered a 16-question questionnare, and their saliva production was measured by Periotron device and by spitting method.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Inclusion criteria

In the psychiatric group, the inclusion criteria was taking specific psychiatric medications.

Exclusion criteria

In the control group the

Design outcomes

Primary

Measure	Time frame	Description
Unstimulated whole saliva flow rate (UWS)	through study completion, an average of 1 year	UWS was determined using the spitting method (Sreebny 2000). Whole saliva was collected for 5 minutes into a previously weighted empty cup, and then measured again after collecting the saliva. The results are in ml/min.
Minor salivary gland (MSG) secretions	Through study completion, an average of 1 year	Palatal and labial MSG flow rates were measured by the Periotron 8010® (Oraflow Inc. Amytiville, USA) device with filter paper discs. The results are transferred into µl/cm2/min.

Outcome results