Sepsis
Conditions
Brief summary
Sepsis is a life-threatening clinical syndrome of organ dysfunction caused by dysregulation of the body's response to infection, and is a common cause of ICU admission for critically ill patients, posing a serious threat to human health. The study demonstrated that hemopexin injection significantly reduced the 28-day all-cause mortality rate of sepsis patients, and this study clarified the specific target and molecular mechanism of hemopexin injection in the treatment of sepsis, which may be of great scientific significance and clinical value for the precise treatment of sepsis and the research and development of new drugs.
Interventions
None listed
Sponsors
Southeast University, China
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
1. Meeting the Sepsis 3.0 diagnostic criteria; 2. SOFA score ≥ 2 and \< 13; 3. Signed informed consent.
Exclusion criteria
1. Age \<18 years or \>75 years; 2. Pregnant or lactating women; 3. Presence of severe primary diseases including malignant tumors severe hematologic disorders and HIV infection; 4. Current use of immunosuppressants or history of organ transplantation within the past 6 months; 5. Comorbidities that significantly affect vascular endothelial structure and function such as acute myocardial infarction.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Single-cell transcriptomic analysis of inflammatory and metabolic gene expression, measured using scRNA-seq, with data summarized as differential expression profiles. | Day7 | Single-cell transcriptomic analysis of inflammatory and metabolic gene expression, measured using scRNA-seq, with data summarized as differential expression profiles. |
Outcome results
None listed