Acute Respiratory Distress Syndrome, Mechanical Ventilation
Conditions
Brief summary
With the exception of setting the positive end-expiratory pressure (PEEP), the expiratory phase is commonly overlooked during MV. The expiratory time constant (RCexp) plays an important role in understanding the mechanical properties of the respiratory system in patients receiving mechanical ventilation. However, it is unclear that the effect of expiratory time constant on the ventilation and perfusion distribution.
Detailed description
With the exception of setting the positive end-expiratory pressure (PEEP), the expiratory phase is commonly overlooked during MV. The expiratory time constant (RCexp) plays an important role in understanding the mechanical properties of the respiratory system in patients receiving mechanical ventilation. However, it is unclear that the effect of expiratory time constant on the ventilation and perfusion distribution.
Interventions
OTHERRCexp
patients received different RCexp
Sponsors
Southeast University, China
Study design
Observational model
CASE_CROSSOVER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
adult patients with ARDS receiving mechanical ventilation no more than 72 hours
Exclusion criteria
1. age \<18 years old 2. patient undergoing legal protection 3. contra-indications to EIT (e. g. severe chest trauma or wounds) 4. pneumothorax 5. patient undergoing ECMO 6. pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Difference in ventilation/perfusion mismatch | 4 hours | ventilation/perfusion mismatch is measured by EIT |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Difference in dead space | 4 hours | dead space is measured by EIT |
| Difference in shunt | 4 hours | shunt is measured by EIT |
Countries
China
Contacts
Primary Contactyuan xue yan, MD
Outcome results
None listed