Working Memory, Inhibitory Control, Mild Cognitive Impairment (MCI), Aging
Conditions
Keywords
Cognitive Training, Working Memory, MCI, Inhibitory Control, Mild Cognitive Impairment, Aging
Brief summary
The goal of this clinical trial is to learn if engaging with an digital intervention may improve cognitive function. The main questions it aims to answer are: 1. Does engagement in with a digital intervention improve working memory? 2. Does engagement in with a digital intervention improve inhibitory control? Researchers will compare two different digital interventions to assess whether they may be helpful in improving cognitive function. Participants will conduct study activities remotely (e.g., at-home): 1. Baseline Assessment. Complete a series of cognitive assessments and surveys. 2. Intervention. Engage in a digital intervention for up to 8 weeks. 3. Post Intervention Assessment. Complete the same cognitive assessments and surveys as the Baseline Assessment. 4. Follow-Up Assessment. Six months after the intervention ends, participants will complete the same cognitive assessments and surveys as the Baseline Assessment.
Detailed description
During the Baseline Assessment, participants will complete web-based cognitive assessments and surveys. The assessments will address various cognitive functions including working memory, long-term memory, inhibitory control, and sustained attention. Surveys will include a characterization of expectancy for the intervention, ratings of stress, and background health information. The Baseline Assessment will take up to 120 minutes and can be completed across more than one session. During the Intervention, participants will be provided an iPad tablet to engage with the assigned intervention app. Participants will be randomly assigned to one of two intervention apps. Regardless of the assigned intervention, participants will engage with the app for 25-45 minutes of training per day, 5 days a week for up to 8 weeks for a total of 1000 minutes of training. After the intervention, participants will complete a Post Intervention Assessment and 6 month later, a Follow-Up Assessment. Both of these assessment periods will consist of the same cognitive assessments and surveys as conducted during the Baseline Assessment. Upon completion of all study activities, participants will be able to keep the iPad as a gift for their voluntary participation.
Interventions
Sponsors
University of California, San Francisco
National Institute on Aging (NIA)
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
60 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* Minimum of 12 years of education * English fluency * Normal or corrected-to-normal vision * Normal or corrected-to-normal vision * Medically healthy older adults including those with below-average cognitive performance or mild cognitive impairment patients without dementia
Exclusion criteria
* Under the age of 60 * Clinical diagnosis of neurological or psychiatric disorder * Visually or hearing impaired without correction to normal * Clinical diagnosis of dementia or AD8 score of \>3 * Regularly (one or more times per week) practicing an instrument within the last year * 10 or more years of formal musical instrument training
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Working Memory | Immediately before the intervention, Immediately after the intervention, 6 months after the intervention | Working memory performance will be assessed with a delayed match-to-sample task. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Inhibitory Control | Immediately before the intervention, Immediately after the intervention, 6 months after the intervention | Inhibitory control will be assessed with the Stroop task. |
Countries
United States
Contacts
CONTACTMelissa Arioli
PRINCIPAL_INVESTIGATORTheodore Zanto, PhD
University of California, San Francisco
Outcome results
None listed