Food Allergy in Children
Conditions
Brief summary
All children sensitized to lupine who have performed an oral food challenge (OFC) to lupine between January 2017 and May 2024 in the Pediatric Allergy Unit of the University Hospital of Nancy were included. Retrospective data regarding food and respiratory allergies were collected as well as information regarding lupine skin prick test (SPT), specific IgE (sIgE) and OFC. Severity of allergic reaction was evaluated by CoFAR grade and reactogenic cumulative threshold dose. Aims of this study were (i) to assess relevance of sensitization to lupine in children and (ii) to describe severity of reactions in case of allergy.
Interventions
OTHERNo intervention
Sponsors
Central Hospital, Nancy, France
Study design
Observational model
OTHER
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* cutaneous or biological sensitization to lupine
Exclusion criteria
* oral food challenge done with something other than lupine flour
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| diagnostic value of prick test and specific IgE | baseline | prick test to lupine flour in mm done during interview and collected retrospectively Specific IgE in kU/L to lupine seed done during same interview and collected retrospectively prick test and sIgE done as in usual clinical practice main outcome of the study are statistical tests (ROC curve) done to analyse diagnostic values of prick test and sIgE in this population |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| severity of allergic reaction in oral food challenge | baseline | grading the severity of allergic reaction in oral food challenge with lupine flour using CoFAR scale retrospectively |
Outcome results
None listed