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SMART Pilot Trial of Glycemic Screening Outreach

SMART Pilot Trial of Glycemic Screening Outreach

Status
Enrolling by invitation
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06915194
Enrollment
105
Registered
2025-04-08
Start date
2025-07-08
Completion date
2025-11-08
Last updated
2025-07-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Overweight (BMI > 25), Obesity

Keywords

diabetes screening

Brief summary

Approximately 130 million Americans have prediabetes or type 2 diabetes (T2D) but remain unscreened and/or unaware of their diagnosis. While prediabetes/T2D screening, also known as glycemic screening, is endorsed in national guidelines, there is almost no research on how to increase screening rates, or evaluations of interventions testing the effectiveness of screening promotion strategies. The American Medical Association has published prediabetes quality measures that apply to UCLA Health as well as all other health systems, specifically tracking the percentage of adult patients with risk factors for T2D due for glycemic screening for whom the screening process was initiated. However, there is no current systemic effort underway at UCLA, or most other health systems, to encourage glycemic screening. We are proposing a pilot trial of the first SMART (Sequential Multiple Assignment Randomized Trial) for glycemic screening. Our SMART experiment will provide preliminary feasibility and acceptability data for a larger, multisite trial that will provide vital guidance to optimize screening approaches for a growing number of screening-eligible patients so that they may seek earlier detection, treatment, and/or access to lifestyle programs and interventions for T2D or prediabetes.

Interventions

BEHAVIORALText message

Participants receive a text message encouraging glycemic screening

Participants receive a patient portal message encouraging glycemic screening

BEHAVIORALMailed letter

Participants receive a mailed letter encouraging glycemic screening

Sponsors

University of California, Los Angeles
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
SCREENING
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
35 Years to 70 Years
Healthy volunteers
No

Inclusion criteria

* Overweight or obese

Exclusion criteria

* Existing type 2 diabetes, A1c drawn within past 3 years

Design outcomes

Primary

MeasureTime frameDescription
Hemoglobin A1c90 daysReceipt of hemoglobin A1c screening for dysglycemia

Secondary

MeasureTime frameDescription
Acceptability survey90 daysParticipants will receive a Qualtrics survey with the following 5 items: 1. How did you feel about the messages recommending that you come in for a blood test to check your hemoglobin A1c (blood sugar) level? 2. How clear were the messages recommending that you come in for a blood test to check your hemoglobin A1c (blood sugar) level? 3. Did the messages affect the chances that you would get the hemoglobin A1c (blood sugar) level? 4. Did the messages cause you any anxiety or stress? 5. How concerned were you that the messages were from scammers not associated with UCLA?

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026