Antecolic Versus Retrocolic Gastrojejunostomy During Whipple's Procedure

Antecolic Versus Retrocolic Gastrojejunostomy Following Pancreaticoduodenectomy: a Prospective Randomised Study

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06914349

Enrollment

Registered

2025-04-06

Start date

2025-03-30

Completion date

2029-03-31

Last updated

2025-06-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pancreas Neoplasms, Pancreatic Cancer Resectable

Keywords

Gastrojejunostomy, Whipple's, Antecolic, Retrocolic

Brief summary

Aim: This randomized clinical study aims to compare occurrence of DGE in patients undergoing either antecolic or retrocolic gastrojejunostomy following pancreaticoduodenectomy. Methods: Participants of this study will be patients undergoing pylorus preserving pancreaticoduodenectomy at the Surgical Department of the University Hospital of Larissa. Patients will be randomized to undergo either an antecolic or a retrocolic gastrojejunostomy and the occurrence of DGE will then be compared between the two groups. Individuals younger than 18 or older than 75 years old, as well as patients who do not consent to participate in this trial, will be excluded. Expected results: Based on available literature, antecolic gastrojejunostomy may be related with a lower incidence of DGE, without a statistically significant difference between the two methods. We aim to show if one of the two methods of gastrointestinal reconstruction (antecolic versus retrocolic) affects DGE.

Interventions

PROCEDUREAntecolic gastrojejunostomy

Gastrojejunostomy in front of the transverse colon

PROCEDURERetrocolic gastrojejunostomy

Gastrojejunostomy through the transverse mesocolon

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Age over 18 years old * Elective pancreaticoduodenectomy * Signed consent form

Exclusion criteria

* Age under 18 years old * Patients who are participants in other trials that may affect the results of this study * Patients who do not consent to participate in the study

Design outcomes

Primary

Measure	Time frame	Description
Delayed Gastric Emptying	3 years	The occurence of delayed gastric emptying will be compared between two groups of patients: those who undergo an antecolic gastrojejunostomy and those who undergo a retrocolic approach.

Countries

Greece

Contacts

Primary ContactChrysoula C Kolla

christinakolla@yahoo.gr+306983075706

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026