Inflammatory Bowel Diseases, Neutropenia, Nudt15 Deficiency
Conditions
Brief summary
The study will include participants who were diagnosed with inflammatory disease and followed up at National Taiwan University Children's Hospital. The investigators will check the NUDT15 gene test, if the participant agrees to do an additional blood test. The result of the gene test will be analyzed and compared with other clinical data.
Detailed description
In inflammatory bowel disease (IBD), thiopurines play an important role in maintenance of steroid-free remission but possess risk of life-threatening neutropenia, which is associated with gene variants of NUDT15 in Asians. In order to better incorporate thiopurines in clinical practice, the investigators aim to summarize the prevalence and impacts of NUDT15 variation in IBD in Taiwan. The study will include participants who were diagnosed with inflammatory disease and followed up at National Taiwan University Children's Hospital. The investigators will check the NUDT15 gene test, if the participant agrees to do an additional blood test. The result of the gene test will be analyzed and compared with other clinical data.
Interventions
None listed
Sponsors
National Taiwan University Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Years to 25 Years
Healthy volunteers
No
Inclusion criteria
* Participants who are diagnosed with inflammatory bowel disease.
Exclusion criteria
* Participants who refused to have blood test for NUDT15 gene evaluation.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Neutropenia | 2 years | Neutropenia is defined as absolute neutrophil count \<1500/microL, and severe neutropenia is defined as absolute neutrophil count \<500/microL. |
Countries
Taiwan
Contacts
Primary ContactWei-Ting Chen, MD
Backup ContactJia-Feng Wu, MD, PhD
Outcome results
None listed