HIV Infection
Conditions
Keywords
HIV genetic diversity, HIV-1 non-M variants
Brief summary
The aim of the study is to study the genotypic characteristics of HIV-1 non-M circulating in the whole Cameroon and their genetic evolution.
Detailed description
HIV-1 is divided four distinct groups: M (major) which represents the pandemic strains while others groups O (outlier), N (non M, non O) and P are called non-M variants. Group O (HIV-O) is more divergent, endemic in Central Africa and Cameroon, where it represents about 1% of HIV infections. These variants are characterized by an important genetic divergence from pandemic HIV-1 group M (HIV-M), which impacts on the diagnosis, monitoring and treatment of infected patients. Although discovered in 1990, and emerged at the same time as HIV-M, no data of epidemiology, natural history and evolution of the genetic diversity of these variants is currently available. The few knowledge available to date come from sporadic cases, mainly through studies in Yaoundé. It is therefore essential to improve current knowledge on these variants and their consequences on infected patients. The aim of the study is to study the genotypic characteristics of HIV-1 non-M circulating in the whole Cameroon and their genetic evolution.
Interventions
DIAGNOSTIC_TESTProspective
Blood samples will be collected in order to meet the objectives of this substudy and possibly for complementary research
Sponsors
University Hospital, Rouen
Centre Pasteur du Cameroun
ANRS, Emerging Infectious Diseases
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
21 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All available samples tested positive for HIV during the national Health survey of Cameroon in 2011 And 2018 * All Individuals who came to Centre Pasteur in Yaoundé or Garoua for HIV screening or viral load monitoring.
Exclusion criteria
* Insufficient quantity or degraded Dried Blood Spot samples * All HIV-positive individuals aged less than 21 years, infected with a Group M HIV-1 virus, or those who refused to participate in the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of non-M HIV-1 in Cameroon | 1 day | Number of participants infected with non-M HIV-1 included compared to the total expected number of inclusions |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Investigate the current molecular epidemiology of resistance in non-M HIV-1 variants in Cameroon | 1 Day | Proportion of non-M HIV-1 samples characterized genotypically among the samples collected from participants included in the project |
Other
| Measure | Time frame | Description |
|---|---|---|
| Study the current molecular epidemiology of HIV 1 non-M variant resistance in Cameroon | 1 day | Proportion of non-M HIV-1 samples characterized for resistance among the samples collected from participants included in the project |
Contacts
Primary ContactMariam Gharib, PhD
Backup ContactElodie Alessandri-Gradt, ParmD PhD
Outcome results
None listed