Evaluation of Central Corneal Thickness in Patients With Vernal Keratoconjunctivitis Using Topical Steroids

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06913790

Enrollment

Registered

2025-04-06

Start date

2025-03-20

Completion date

2026-02-20

Last updated

2025-04-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vernal Keratoconjunctivitis

Brief summary

This prospective observational cohort study aims to assess changes in central corneal thickness (CCT) in vernal keratoconjunctivitis (VKC) patients using topical steroids. Data will be collected from tertiary care hospitals such as Al-Mustafa eye hospital and Jinnah Hospital, Lahore.

Detailed description

A total of 34 participants, including an adjustment for a 10% dropout rate, will be recruited using purposive sampling. The study will last six months. Eligible participants (aged 5-25 years) must have a confirmed VKC diagnosis and be on topical steroids, with exclusions for prior ocular surgery, systemic steroid use, and contact lens wear. Baseline assessments will include demographic data, VKC severity, and CCT measurements via pachymetry and optical coherence tomography. Follow-up evaluations at one and three months will track CCT changes. A paired t-test will compare baseline and follow-up measurements. This study will help understand the impact of topical steroids on CCT in VKC patients.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

5 Years to 25 Years

Healthy volunteers

Inclusion criteria

* Young adults aged between 5-25 years * Confirmed diagnosis of VKC * Currently prescribe topical steroid e.g, dexamethasone, prednisolone * No prior history of corneal surgery or trauma * Willing to attend follow-up visits and comply with the treatment protocol.

Exclusion criteria

* History of ocular surgery or trauma * Presence of other corneal pathologies (e.g., Keratoconus) * Systemic immunosuppressant use or history of systemic steroid use in the past 06 months * Use of other medications that could influence corneal thickness e.g, antiglaucoma drugs * Contact lens use within 1 month prior to the study * Severe dry eye or another ocular surface disease

Design outcomes

Primary

Measure	Time frame	Description
Slit Lamp Test	12 Months	A slit lamp exam, a common eye test, uses a microscope and a focused light beam to examine the front and back of the eye, aiding in the diagnosis of various conditions, and often involves scoring or grading for certain aspects like cell and flar

Countries

Pakistan

Outcome results