The Impact of Hypothyroidism on Tear Production and Dry Eye Symptoms: Implications for Optometric Care

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06913465

Enrollment

Registered

2025-04-06

Start date

2025-03-20

Completion date

2026-02-20

Last updated

2025-04-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dry Eye Syndromes

Brief summary

This observational cross-sectional study will assess the impact of hypothyroidism on tear production and tear film stability. Conducted at DHQ Hospital dera ghazi khan over six months, the study will recruit 71 participants aged 20-60 years using a non-probability convenience sampling method. Patients with confirmed hypothyroidism will undergo tear assessment through the Schirmer I test, Tear Breakup Time (TBUT) test, and Ocular Surface Disease Index (OSDI) questionnaire. The Schirmer test will measure tear production, while TBUT will assess tear film stability.

Detailed description

Ocular surface staining and tear osmolarity will further evaluate ocular health. Patients with systemic conditions affecting tear production, such as diabetes or rheumatoid arthritis, will be excluded. The collected data will be analyzed to determine the relationship between hypothyroidism and dry eye symptoms, aiding in better management of ocular health in hypothyroid patients. The study aims to provide valuable insights into the association between thyroid dysfunction and tear film abnormalities.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 60 Years

Healthy volunteers

Inclusion criteria

* Age between 20-60 years. * Confirmed diagnosis of hypothyroidism with thyroid function tests. * No prior history of ocular surgery or significant ocular pathology.

Exclusion criteria

* Use of systemic medications affecting tear production (e.g., antihistamines, diuretics). * Other systemic conditions (e.g., diabetes, rheumatoid arthritis). * Pregnancy or lactation

Design outcomes

Primary

Measure	Time frame	Description
The Ocular Surface Disease Index (OSDI)	12 Months	The Ocular Surface Disease Index (OSDI) is a 12-question questionnaire used to assess the severity of dry eye symptoms and their impact on vision-related function, scored on a scale of 0 to 100, with higher scores indicating greater disability.

Countries

Pakistan

Outcome results