Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06911229

Enrollment

Registered

2025-04-04

Start date

2025-10-01

Completion date

2027-07-31

Last updated

2026-07-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson Disease

Keywords

Freezing of gait, deep brain stimulation

Brief summary

Locomotor adaptation will be studied using an established split-belt treadmill paradigm, consisting of baseline (1:1 speed ratio), split-belt adaptation (2:1) and post-adaptation (1:1) walking. Split-belt walking will be performed under DBS ON and DBS OFF conditions, while off-medication.

Detailed description

We will test the hypotheses that DBS can facilitate split-belt walking adaptation with DBS ON compared with DBS OFF.

Interventions

DEVICEDeep Brain Stimulation (DBS)

Patients will receive DBS in the clinically-optimized setting.

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* consensus diagnosis of idiopathic PD by fellowship trained movement disorders neurologists at the Normal Fixel Institute of Neurological Diseases; * chronically stable DBS, defined as having had DBS for at least 6 months in duration with optimized DBS settings; * Age between 18 - 80 years old per the FDA data sheet for PD DBS; * no dementia according to the clinical diagnostic criteria for PD dementia; * ambulatory without the use of walking aids, or another person's assistance.

Exclusion criteria

* other previous neurological surgery; * suspicion of other neurologic diagnoses such as atypical parkinsonism, or Alzheimer's disease.

Design outcomes

Primary

Measure	Time frame	Description
Step length rate of adaptation	1 hour	The rate of adaptation in step length asymmetry is estimated by fitting an exponential decay function to step length asymmetry over the first 100 strides in adaptation.
Step length magnitude of adaptation	1 hour	The magnitude of adaptation in step length asymmetry is calculated as the mean difference in step length asymmetry between early and late adaptation.
Step length after-effects	1 hour	The after-effect in step length asymmetry is calculated as the mean difference in step length asymmetry between baseline and early post-adaptation.

Countries

United States

Contacts

CONTACTJulia Choi, Ph.D.

juliachoi@ufl.edu3522941720

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jul 16, 2026