Malignant Pleural Mesothelioma
Conditions
Brief summary
Malignant Pleural Mesothelioma is an aggressive and refractory disease , the most aggressive treatment plan offered to these patients include trimodalitiy approach with chemotherapy as the mainstay of treatment . the rationale of post operative Radiotherapy is to sterilize the post operative volume to reduce local failure meanwhile minimizing toxicities in this trial we are going to assess the safety and efficacy of Radiotherapy in Mesothelioma patients poat Pleural decortication
Detailed description
This study will include malignant Pleural Mesothelioma patients treated by trimodalitiy approach starting with neoadjuvant chemotherapy followed by surgery in the form of Pleural decortication then all patients will receive post operative hemithoracic radiation
Interventions
RADIATIONhemithoracic Volumetric Arc Radiotherapy post Pleural decortication
post operative delivery of hemithoracic Volumetric Arc Radiotherapy
Sponsors
Cairo University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Evidence of metastatic disease. * Underwent Pleural decortication. * Able to provide informed consent.
Exclusion criteria
* Poor pulmonary function tests. * Recurrent or palliative cases. * Inability to attend full course of Radiotherapy or follow up visits.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Acute Radiation Toxicity | weekly assessment during radiation course and monthly follow up for the first 6 months | Questionnaire based Follow up about acute Radiation toxicity according to RTOG including dysnea , cough , chest pain , dysnea on effort from grade 1-5 |
| late radiation toxicity | Bi-monthly fashion of minimum 6 months post radiation course | follow up of patients using both Questionnaire and performing pulmonary function tests and Echo , focusing on DLCO & FEV1 |
Countries
Egypt
Contacts
Primary ContactGamal
Outcome results
None listed