D Vitamin and Alveolar Macrophages in Idiopathic Pulmonal Fibrosis

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06909409

Enrollment

120

Registered

2025-04-03

Start date

2024-10-11

Completion date

2026-10-11

Last updated

2025-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Idiopathic Pulmonary Fibrosis (IPF)

Keywords

Idiopathic pulmonary fibrosis, pulmonary macrophages, alveolar macrophages, vitamin D, Soluble CD163, Soluble CD206

Brief summary

The goal of this observational study is to gain deeper insights into human macrophages and vitamin D, and their interplay, within Idiopathic Pulmonary Fibrosis (IPF). The overall questions, it aims to answer, are the following: Do IPF patients suffer from systemic and local (pulmonary) insufficient levels of vitamin D? Do IPF patients suffer from pro-fibrotic and pro-inflammatory pulmonary macrophages?

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* A clinical diagnosis of IPF, non-IPF ILD or lung cancer * A signed informed consent

Exclusion criteria

* Do not speak Danish/Do not understand Danish

Design outcomes

Primary

Measure	Time frame	Description
Vitamin D status	At enrollment	Significant change in vitamin D levels in systemic (blood) and local (pulmonary) metabolism.
Pulmonary macrophages	At enrollment	Significant change in alveolar macrophage phenotype

Secondary

Measure	Time frame	Description
Biomarker levels in blood and BAL samples	At enrollment	Significant change in levels of macrophage and inflammatory/fibrotic biomarkers

Countries

Denmark

Outcome results