Correlations Between Cerebral Motor Control During a Manual Task and During an Articulatory Task
Conditions
Keywords
Motor skills, speech, cortical
Brief summary
The aim of this study is to examine the relationship between cerebral motor control during a manual task and during an articulary task, using functional MRI in a cohort or young adults aged between 18 and 35. The literature reveals a well-established relationship between manual motor skills and speech from an anatomical and functional point of view. Some studies indicate a proximity between the motor cortical regions corresponding to the hand and the mouth, with a mutual interaction of the two functions from the earliest stages of life (for example, the Babkin reflex). Experimental data shows that hand movements can be influenced by mouth movements. Neurophysiological studies have demonstrated the existence of a link between these two systems in humans and monkeys. To date, no study has identified the common cortical networks that are active during these two limb movements in a given sample of subjects. The aim of this study is to determine whether such networks exist. The results could be therapeutically relevant, particularly for stroke patients, by enabling more effective restoration of articulatory abilities through complementary limb movements.
Interventions
OTHERTasks learning and MRI scan
\- 2-week learning and training phase of motor tasks and oral and facial language (OLF) tasks. Manual fine motor tasks will correspond to activities requiring increasing precision and different types of grip (crushing a ball, modelling clay with the palm of the hand, sorting round coins with thumb/index pliers). The OLF praxis tasks will correspond to coordinated movements of different parts of the face (cheeks, lips and tongue). \- MRI (magnetic resonance imaging) exam, During this exam, the investigator will give to the subject instructions for a task to be carried out. These tasks will correspond to the motor tasks previously trained.
Sponsors
Centre Hospitalier Universitaire de Nice
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
Category 2 pilot study involving healthy subjects.
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
1. Male or female between the ages of 18 and 35 2. Right-handed 3. Member of beneficiary of a social security insurance 4. Signature of an informed consent
Exclusion criteria
1. Disorders of fine manual motor skills and/or articulatory disorders 2. A neurological history that has affected the subject's cerebral function (stroke, head injury) 3. Contraindication to MRI (presence of ferromagnetic material in the body, claustrophobia) 4. Pregnant women 5. Taking medication that may alter the cerebral haemodynamic signal
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Recording of brain activity during manual motor skills and speech articulation | 2 weeks after inclusion | Detection and comparison of fMRI image sequences of brain areas based on variations in the difference between oxygenated and deoxygenated hemoglobin during manual motor tasks and silent phoneme articulation |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORGuillaume SACCO
Centre Hospitalier Universitaire de Nice
Outcome results
None listed