Comparison of Sevoflurane and Propofol on ANI

Comparison of Sevoflurane and Propofol on ANI in Patients Undergoing General Anesthesia: a Prospective Randomized Controlled Study

Status

Not yet recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06907823

Enrollment

Registered

2025-04-02

Start date

2025-06-30

Completion date

2025-12-31

Last updated

2025-06-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Analgesia Nociception Index, Propofol, Sevoflurane

Brief summary

The goal of this clinical trial is to compare the effect of sevoflurane and propofol on analgesia nociception index(ANI) in patients undergoing general anesthesia. The main question it aims to answer is whether propofol anesthesia results in lesser ANI change to a nociceptive stimulation compared to sevoflurane.

Detailed description

Patients will be allocated to either propofol or sevoflurane group. Nociceptive event will be defined as long-lasting tetanic stimulation, square-wave, duration of 30 seconds , amplitude of 50mA, frequency of 50 Hz. analgesia nociception index value and hemodynamic parameters will be recorded 1-minute before and after nociceptive event.

Interventions

DRUGpropofol

propofol anesthesia

DRUGSevoflurane

sevoflurane anesthesia

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

19 Years to No maximum

Healthy volunteers

Inclusion criteria

* American society of anesthesiologists physical status class I or II

Exclusion criteria

* history of drugs that can affect the central nervous system and autonomic nervous system, such as anticholinergics, betablockers, antidepressants..etc. * history of allergic reaction to sevoflurane and/or propofol * history of and/or family history of malignant hyperthermia * neurodegenerative disorder * psychiatric disorder * arrhythmia * diabetes mellitus * drug abuse history

Design outcomes

Primary

Measure	Time frame	Description
analgesia nociception index change	During anesthesia period	analgesia nociception index value 1-minute before tetanic stimulation and 1-minute after tetanic stimulation

Secondary

Measure	Time frame	Description
Hemodynamic change	During anesthesia period	Blood pressure change 1 minute before tetanic stimuation and 1 minute after tetanic stimulation

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026