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Thick Cornea with High Back Elevation

Long Term Follow-up Study on Thick Cornea with High Back Elevation

Status
Not yet recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06905977
Enrollment
40
Registered
2025-04-02
Start date
2025-05-01
Completion date
2026-06-30
Last updated
2025-04-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Corneal Thickness Measurement

Brief summary

To follow up cases of thick cornea with high back elevation by pentacam.

Detailed description

The cornea plays a crucial role in refraction and so help in good visual acuity. with its thickness and back elevation being essential parameters in diagnosing and managing corneal diseases such as keratoconus. The normal human cornea has a central thickness of approximately 540-550 µm. The periphery is generally thicker, reaching up to 700 µm. Corneal thickness is influenced by genetics, hydration, and intraocular pressure.Thick Cornea (\> 540 µm): Seen in conditions such as corneal edema and Fuchs' dystrophy. Thin Cornea (\< 500 µm): Observed in keratoconus, LASIK-induced thinning, and corneal ectasia. Back corneal elevation is assessed using corneal topography or tomography, typically referenced to a best-fit sphere (BFS). In normal cases, Back corneal elevation is usually ≤12 µm above the BFS, indicating a structurally healthy cornea without signs of ectasia. Susceptible elevation ranges between 12-20 µm, which may be an early indicator of corneal instability, such as subclinical keratoconus. Therefore, it should be evaluated alongside other parameters, including pachymetry, anterior curvature, and biomechanical properties. Abnormal back corneal elevation is generally considered \>20 µm, particularly if localized or asymmetric, and is strongly associated with corneal ectatic disorders such as keratoconus, pellucid marginal degeneration, or post-LASIK ectasia. This abnormal elevation is often accompanied by other risk factors, including increased posterior corneal curvature, corneal thinning, and significant asymmetry, necessitating further assessment and monitoring. Many cases of thick cornea are associated with high back elevation and this discourage refractive surgery in such cases so in investigator's study the investigator will follow up these cases to determine if these corneas are considered normal corneas or not.

Interventions

DEVICEpentacam

we will follow up on cases of thick cornea with high back elevation

Sponsors

Assiut University
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
6 Years to No maximum

Inclusion criteria

Any patient can interact with pentacam. Both Genders: include both males and females. Patients with thick cornea (\>540 µm) with high back elevation.

Exclusion criteria

* Patients with any eye disease (significant cataract or unstable glaucoma) * Uncontrolled external disease such as blepharitis , moderate to severe dry eye and allergy. * Patient with ocular disease such as uveitis, post herpetic infection and corneal opacity

Design outcomes

Primary

MeasureTime frameDescription
Measurement of corneal thickness and back corneal elevation by pentacam deviceBaselineThe investigator will image the cornea to measure corneal thickness and back corneal elevation using the Pentacam device and follow up for cases of thick corneas with high back elevation at 3 months, 6 months, and 1 year.

Contacts

Primary ContactMerna Fily
mernamagdyfily24@gmail.com01226081248
Backup ContactAhmed Fathalla, Professor
ahmedfathalla308@aun.edu.eg01223971401

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026