Skip to content

Isometric Contraction-Based Pain Modulation Versus Eccentric Strengthening in Treating Achilles Tendinopathy

Isometric Contraction-Based Pain Modulation Versus Eccentric Strengthening in Treating Achilles Tendinopathy

Status
Active, not recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06905743
Enrollment
38
Registered
2025-04-01
Start date
2025-03-20
Completion date
2026-02-20
Last updated
2025-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Achilles Tendinopathy

Brief summary

Achilles tendinopathy is a common overuse injury that leads to pain and functional limitations. Traditional rehabilitation focuses on eccentric strengthening, which has been widely studied for its benefits in promoting tendon remodeling and improving strength. However, recent research suggests that isometric contractions may offer superior pain modulation effects, especially in the early stages of rehabilitation.

Detailed description

This study aims to compare the effectiveness of isometric contraction-based pain modulation versus eccentric strengthening in treating Achilles tendinopathy. Isometric exercises involve maintaining a static muscle contraction, which has been shown to reduce pain through neuromuscular mechanisms, potentially making it a valuable alternative or complement to eccentric loading.

Interventions

DIAGNOSTIC_TESTIsometric Contraction-Based Pain Modulation Protocol for Achilles Tendinopathy

The standard recommendation for tendinopathy rehab became 30 to 45 second heavy isometric contractions repeated for 3 to 5 repetitions

COMBINATION_PRODUCTEccentric Strengthening (Alfredson's Protocol for Achilles Tendinopathy )

The eccentric loading protocol, popularized by the research of Alfredson, consisted of 3 sets of 15 for both bent knee and straight knee heel raises with each heel lowering lasting 3-seconds

Sponsors

Superior University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
No

Inclusion criteria

* Clinically Diagnosed with Achilles Tendinopathy using MRI * At least 3 months incidence period of Achilles Tendinopathy * Must be able to attend all treatment sessions and follow-up assessments. * Ability to walk independently without any assistive devices.

Exclusion criteria

* Severely restricted ROM of ankle * Patients who underwent surgery for Achilles tendinopathy * Patients who had undergone previous surgery of lower limb extremity * Those using ankle orthosis * Patients with systemic diseases affecting ankle (osteoarthritis, rheumatoid arthritis, and osteoporosis) * Individuals with neurological disorders affecting the lower limbs. * Systemic Conditions like diabetes, cardiovascular diseases.

Design outcomes

Primary

MeasureTime frameDescription
NUMERIC PAIN RATING SCALE (NPRS):12 MonthsThe Numeric Pain Rating Scale is a widely used, reliable, and user-friendly tool for assessing an individual's level of pain (NPRS). The patient is required to rate their level of discomfort using a self-reported scale with a range of 0 to 10, where 0 indicates no pain and 10 indicates the most excruciating pain.
PRESSURE ALGOMETRY:12 MonthsThe pressure pain threshold (PPT), or the lowest force that causes pain in a particular body part, can be objectively measured using pressure algometry. To test sensitivity and identify shifts in pain perception, a portable instrument called a pressure algometer gently and gradually applies pressure to tissue, such as muscles or tendons. Pressure Algometry offers a methodical, objective way to measure pain sensitivity, which is commonly utilized in clinical and research contexts. It is frequently used to evaluate tenderness and pain in musculoskeletal issues, myofascial pain, and tendinopathy. Pressure algometry is a widely used tool to assess mechanical pain sensitivity by applying controlled pressure to a specific area and measuring the pain threshold. Its reliability is well-established, with intra-rater reliability coefficients ranging from 0.70 to 0.94, depending on the site of application and methodological consistency .

Countries

Pakistan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026