Kidney Function Tests
Conditions
Keywords
Glomerular Filtration Rate, neutrophils, obesity, serum creatinine, walking training, white blood cells
Brief summary
The goal of this clinical trial is to investigate the impact of a 10-week moderate intensity interval walking training (MIIWT) program on kidney function markers in obese postmenopausal women. The main question it aims to answer is: Does MIIWT improve kidney function markers in this population? Researchers will compare MIIWT (designed to training group) to non-training intervention (designed to control group) to see if the training program works to improve kidney function markers. Participants in training group will: perform a 10-week MIIWT program, four sessions per week (5 repetitions of 6-min-walking-test (6MWT) at 60-80% of 6MWTdistance measured at baseline, interspersed by 6-min of active recovery between repetitions). Participants in control group will : not perform any physical training and maintain their usual daily activities.
Detailed description
The convergence of the obesity pandemic and the postmenopausal status is likely associated with renal function decline. Regular aerobic training have been shown to prevent adverse health outcomes in obese. The main purpose of this study was to evaluate changes in kidney function markers and white blood cell (WBC) subpopulations in obese postmenopausal women participating in moderate intensity interval walking training (MIIWT). A total of 36 obese postmenopausal women were randomized to MIIWT (CON, n=18) or control group (CON, n=18), four times a week for 10-week. The MIIWT consisted on 5 repetitions of walking for 6-min at 60-80% of the 6-min-walk-test-distance with 6-min of active recovery between repetitions. Before and after the MIIWT, body composition, kidney function markers (serum creatinine \[sCr\], blood urea nitrogen \[BUN\], serum uric acid \[sUA\] and Glomerular Filtration Rate \[GFR\] and white blood cells (WBC) count and its specific subpopulations (neutrophils \[NEU\], lymphocytes \[LYM\], monocytes \[MON\], eosinophils \[EOSI\] and basophils \[BASO\]) were assessed.
Interventions
BEHAVIORALwalking intervention
Moderate intensity intermittent walking training for a period of 10 weeks. The intensity of the training is 60 to 80% of 6MWTdistance. The frequency of the training is four times a week.
Sponsors
Wissal Abassi
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
50 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* be aged between 50 and 60 years. * be postmenopausal (absence of menses \> 12 months). * present a BMI greater than or equal to 30 kg/m2. * be free of any special diets in the three months prior to the start of the intervention. * have a sedentary lifestyle (exercise less than 2 h/week).
Exclusion criteria
* Suffering from any cardiovascular/renal/pulmonary/metabolic disease. * Being under menopausal hormone therapy. * Presenting any orthopedic limitations interfering the ability to perform the study intervention.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| basophils | At baseline and at week 11(after the ten weeks of the training intervention). | blood concentration of basophils (BASO) were collected (5 ml) in test tubes containing EDTA and analyzed using an automated cell counter (XN450; Sysmex, Norderstedt, Germany). |
| monocytes | At baseline and at week 11(after the ten weeks of the training intervention). | blood concentration of monocytes (MON) were collected (5 ml) in test tubes containing EDTA and analyzed using an automated cell counter (XN450; Sysmex, Norderstedt, Germany). |
| eosinophils | At baseline and at week 11(after the ten weeks of the training intervention). | blood concentrations of eosinophils (EOSI) ) were collected (5 ml) in test tubes containing EDTA and analyzed using an automated cell counter (XN450; Sysmex, Norderstedt, Germany). |
| serum creatinine | At baseline and at week 11(after the ten weeks of the training intervention). | serum concentrations of creatinine (sCr) are measured from a blood sample (5 ml) using a Chemistry System Analyzer (Beckman Coulter AU480, France). |
| blood urea nitrogen | At baseline and at week 11(after the ten weeks of the training intervention). | serum concentrations of blood urea nitrogen (BUN) are measured from a blood sample (5 ml) using a Chemistry System Analyzer (Beckman Coulter AU480, France). |
| serum uric acid | At baseline and at week 11(after the ten weeks of the training intervention). | serum concentrations of uric acid (sUA) are measured from a blood sample (5 ml) using a Chemistry System Analyzer (Beckman Coulter AU480, France). |
| glomerular Filtration Rate | At baseline and at week 11(after the ten weeks of the training intervention). | the glomerular Filtration Rate (GFR) has been computed using the Cockcroft formula, as follows: GFR (mL/min) = \[(140 - age) × weight ×0.85\]/(sCr× 72). |
| white blood cells count | At baseline and at week 11(after the ten weeks of the training intervention). | blood concentration of white blood cells (WBC) count were collected (5 ml) in test tubes containing EDTA and analyzed using an automated cell counter (XN450; Sysmex, Norderstedt, Germany) |
| neutrophils | At baseline and at week 11(after the ten weeks of the training intervention). | blood concentration of neutrophils (NEU) were collected (5 ml) in test tubes containing EDTA and analyzed using an automated cell counter (XN450; Sysmex, Norderstedt, Germany). |
| lymphocytes | At baseline and at week 11(after the ten weeks of the training intervention). | blood concentrations of lymphocytes (LYM) were collected (5 ml) in test tubes containing EDTA and analyzed using an automated cell counter (XN450; Sysmex, Norderstedt, Germany). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 6 min walking test | At baseline and after ten weeks of the training intervention. | The 6-minute walk test was performed before and after the training intervention as an indicator of exercise capacity. |
| Body composition | At baseline and after ten weeks of the training intervention. | Body composition were determined, with barefoot and lightly dressed subjects, using a stadiometer (Holtain Ltd., UK) and an electronic scale (Tanita BC-533, Tokyo, Japan). |
Countries
Tunisia
Outcome results
None listed