Carpal Tunnel Syndrome (CTS)
Conditions
Brief summary
This study addresses the pressing clinical question of optimizing surgical and pharmacological interventions for severe Carpal Tunnel Syndrome (CTS), a prevalent and debilitating condition caused by median nerve compression. Previous research has established the efficacy of Open Carpal Tunnel Release (OCTR) and Endoscopic Carpal Tunnel Release (ECTR); however, the role of neurotrophic supplementation in enhancing surgical outcomes has yet to be fully elucidated. Using a prospective clinical approach involving 497 patients, we evaluated the comparative outcomes of ECTR and OCTR with or without neurotrophic supplementation. Key findings demonstrate that ECTR, particularly when combined with neurotrophic agents, facilitates faster recovery and greater improvements in Sensory Nerve Conduction Velocity (VCS) and Visual Analog Scale (VAS) scores, with reduced complication rates compared to OCTR
Interventions
PROCEDUREEndoscopic Carpal Tunnel Release
Release of carpal tunnel with endoscopic device
PROCEDUREOpen carpal tunnel release
Release of carpal tunnel with open tecnique
DRUGNeurotrophic supplementation
Neurotrophic supplementation after surgery
Sponsors
University of Bari
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* clinically and electromyographically confirmed severe CTS (SCV \< 35 m/s) * experienced persistent symptoms unresponsive to conservative treatments for at least six months
Exclusion criteria
* mild or moderate CTS * concomitant neuropathies * previous carpal tunnel surgeries * contraindications to neurotrophic supplementation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| SCV evaluation | 12 months of follow-up | SCV will be evaluated through electomyography after ECTR or OCTR with or without neurotrophic supplementation |
| VAS for pain evaluation | 12 months of follow-up | VAS for pain will be evaluated through questionnarie after ECTR or OCTR with or without neurotrophic supplementation |
| VAS for funcionality evaluation | 12 months of follow-up | VAS for functionality will be evaluated through questionnarie after ECTR or OCTR with or without neurotrophic supplementation |
Countries
Italy
Outcome results
None listed