Healthy Adults
Conditions
Brief summary
Intermittent theta-burst stimulation (iTBS) targeting the left dorsolateral prefrontal cortex (DLPFC) is well established in treating patients with major depressive disorder (MDD). However, the iTBS-induced hemodynamic response during or immediately after a full session of stimulation has not been fully investigated. Although several concurrent iTBS/functional Near Infrared Spectroscopy (fNIRS) and iTBS/functional magnetic resonance imaging (fMRI) studies have investigated the hemodynamic response during or immediately after left DLPFC iTBS, they revealed inconsistent findings in the stimulated DLPFC. Given that the variability in iTBS-induced hemodynamic response in the stimulated DLPFC could be modulated by various inter- and intra-individual factors, cross-validating the findings from both techniques (fNIRS and fMRI) in the same group of participants under the same conditions through a simultaneous fMRI/fNIRS setting enables a straightforward comparison and interpretation of results from each technique. However, to our knowledge, cross-validation of iTBS-related fNIRS and simultaneous fMRI data has not been conducted yet, even the implementation of a simultaneous iTBS/fMRI/fNIRS setup is technically feasible with the mutually compatible equipment. Therefore, the current study has two primary objectives: Firstly, to establish a novel and practical methodological pipeline for simultaneously conducting iTBS/fMRI/fNIRS. Secondly, to cross-validate the hemodynamic responses during and immediately after iTBS, respectively monitored by fNIRS and fMRI.
Interventions
DEVICEIntermittent theta burst stimulation (iTBS)
600 pulses (3 pulses × 10 bursts × 20 trains = 600 pulses) will be delivered each session with reference to a 3-minute protocol developed by Huang, et al. (2005). Before, during and after iTBS, both fNIRS and fMRI measurements will be conducted simultaneously.
Sponsors
The Hong Kong Polytechnic University
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* healthiness based on history and psychiatric assessment
Exclusion criteria
* a medical history of a major systemic illness or a neurological or psychiatric disorder * pregnancy * common fNIRS, MRI and TMS
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Oxygenated and deoxygenated hemoglobin (HbO and HbR) change compared to baseline | Before, during and after iTBS stimulation, up to 15 minutes | iTBS-induced HbO and HbR change in the DLPFC before, during and after stimulation |
| BOLD signals | Before, during and after iTBS stimulation, up to 15 minutes | iTBS-induced BOLD change in the DLPFC before, during and after stimulation |
Countries
Hong Kong
Contacts
PRINCIPAL_INVESTIGATORGeorg S. Kranz
The Hong Kong Polytechnic University
Outcome results
None listed