Corticosteroid, Hyaluronic Acid, Laser Therapy, Ozone, Tooth Impaction | {Tooth} | Dental
Conditions
Brief summary
Following the surgical extraction of the most commonly impacted mandibular third molars, the first group was planned to receive methylprednisolone, the second group hyaluronic acid, the third group ozone therapy, the fourth group laser application, and the fifth group only the routine treatment protocol. The study comparatively evaluated the effectiveness of these five groups in preventing complications such as pain, edema, and trismus that may develop after impacted third molar surgery.
Detailed description
The mandibular third molars are the most commonly impacted teeth in the jaws, and their surgical extraction is a frequently performed procedure in oral and maxillofacial surgery clinics. Postoperative pain, trismus, and edema, particularly within the first 48 hours after surgery, significantly impair patients' quality of life. In addition to routinely prescribed medications, various postoperative treatment methods have been explored to minimize or control these complications. Some of the methods reported in the literature include corticosteroid administration, low-level laser therapy, hyaluronic acid application at the extraction site, and ozone therapy. Corticosteroids exert their anti-inflammatory effects by inhibiting both the function and production of certain inflammatory cells. Therefore, they have been widely used for many years to reduce complications following impacted third molar surgery. Low-level laser therapy (LLLT) has anti-inflammatory and analgesic properties, as well as a biostimulatory effect that promotes wound healing. Ozone therapy, due to its antibacterial and anti-inflammatory properties, as well as its ability to accelerate epithelial healing, has been recognized in the literature as a modern, drug-free alternative for managing postoperative complications. Hyaluronic acid (HA) is a member of the glycosaminoglycan family found in various body tissues. Due to its numerous advantages, including the promotion of wound healing, anti-inflammatory, bacteriostatic, and osteoinductive effects, it plays a crucial role in tissue healing and the prevention of postoperative sequelae. This study comparatively evaluates the efficacy of low-level laser therapy, hyaluronic acid, ozone therapy, and methylprednisolone in preventing complications such as pain, edema, and trismus following impacted mandibular third molar surgery, with the aim of improving patients' quality of life.
Interventions
DEVICEDiode laser
A single session was applied to three points of the tooth extraction site.
COMBINATION_PRODUCTHyaluronic acid
1 cc of hyaluronic acid gel was placed into the extraction socket, followed by suturing.
COMBINATION_PRODUCTOzone
Topical ozone was applied to the extraction socket, followed by suturing.
DRUGMethylprednisolone
In addition to the standard prescribed medication, 4 mg of oral methylprednisolone was prescribed postoperatively.
PROCEDUREControl
Only the standard prescribed medication was provided.
Sponsors
Batman University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients classified as American Society of Anesthesiologists (ASA) Class I or II * Age range of 18-35 years * Individuals of both genders * Horizontally impacted teeth with the same angulation according to Winter's classification
Exclusion criteria
* Patients with any pathological condition around the impacted tooth * Pregnant or breastfeeding women * Smokers * Individuals with allergic reactions to the adjuvants or prescribed medications used in the study * Surgical extraction procedures exceeding 30 minutes
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Trismus | All patient data were collected on the 3rd and 7th postoperative days by a researcher blinded to the study groups. | Preoperative maximum mouth opening for trismus (measured as the distance between the upper right and lower right central incisors) was recorded using a Vernier caliper (Mayerbach M003, Germany) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Edema | All patient data were collected on the 3rd and 7th postoperative days by a researcher blinded to the study groups. | For edema assessment, a widely used method in the literature was applied, measuring the linear distances between the lateral canthus-gonion, tragus-pogonion, and tragus-labial commissure points using a flexible measuring tape in direct contact with the skin |
Other
| Measure | Time frame | Description |
|---|---|---|
| Pain Level | All patient data were collected on the 3rd and 7th postoperative days by a researcher blinded to the study groups. | Pain levels were assessed using a visual analog scale (VAS) form, numbered from 1 to 10. For each follow-up period, patients were instructed to mark a value where 0 indicated no pain, 10 represented unbearable pain, and intermediate values reflected varying pain intensities. |
Countries
Turkey (Türkiye)
Outcome results
None listed