Brain Injury, Cardiac Surgery Requiring Cardiopulmonary Bypass, Congenital Heart Defect
Conditions
Brief summary
Patients born with heart defects often undergo surgical procedures on a heart lung machine. With improvements in medical and surgical management, their survival has significantly improved, but their brain insult has not been paid much attention. This study is to determine the relationship between specific proteins in the blood and brain injury in patients less than 18-year-old undergoing heart surgery.
Interventions
Discarded blood samples will be collected from routine clinical labs collected before and after surgery.
Sponsors
Boston Children's Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 18 Years
Healthy volunteers
No
Inclusion criteria
* less than 18 years old * undergoing cardiac surgery with cardiopulmonary bypass at Boston Children's Hospital
Exclusion criteria
* undergoing an emergent procedure and do not have more than 1 hour ahead of time to review the consent * patient in a moribund condition American Society of Anesthesiology (ASA 5) * patient with a hematological and/or oncological disease * Jehovah witnesses * patient on preoperative mechanical ventilation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Characterization of postoperative neurological impairment | 24 hours following surgery | Understand the correlation between measured proinflammatory cytokines and several proteins that are highly expressed in brain cells with postoperative neurological status. |
Countries
United States
Contacts
CONTACTKoichi Yuki, MD
CONTACTRachel Bernier, MPH
Outcome results
None listed