Acute Kidney Injury, Continuous Renal Replacement Therapy, Fluid Overload
Conditions
Brief summary
Hemodynamic tolerance of fluid removal during deresuscitation is a cornerstone of the impact on outcome of such a strategy. However, how to define and to predict hemodynamic tolerance to fluid removal remains controversial. The investigators routinely use a standardized deresuscitation protocol in patients with fluid overload and continuous renal replacement therapy combined with monitoring of clinical and biological perfusion parameters. The aim of the study was to describe perfusion during deresuscitation, and to determine whether it is associated with major adverse kidney events at day 30.
Interventions
OTHERDescribe the perfusion parameters during a deresuscitation strategy and their association with the outcome.
Arterial lactate, pCO2 gap, SvO2, capillary refill time and mottling score anomalies will be described during the first 5 days of the deresuscitation strategy.
Sponsors
Hospices Civils de Lyon
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Age ≥ 18 years old * Acute kidney injury requiring continuous renal replacement therapy * Standardized deresuscitation following a routine care protocol
Exclusion criteria
* Chronic hemodialysis * Advanced directives to withhold or withdraw life-sustaining treatment, * Patient's opposition to the use of his/her personal health data
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| MAKE 30 | A day 30 after the initiation of the deresuscitation strategy | Major adverse kidney event at day 30, defined as follows: * Death OR * No weaning of renal replacement therapy OR * Serum creatinine \> 2 times baseline serum creatinine |
Countries
France
Outcome results
None listed