Cancer of the Lung, Lung Cancer
Conditions
Keywords
Lung cancer screening (LCS), Pink and Pearl Campaign, Breast cancer screening (BCS), Low-dose computed tomography (LDCT), Smoking history, Health disparities, Screening behavior, Feasibility, Acceptability, Appropriateness
Brief summary
The investigators proposal is ripe for executing as the investigators seek to leverage this "natural experiment" initiated by the BJC health system to evaluate the effectiveness of the Pink & Pearl Campaign as an implementation strategy to promote lung cancer screening (LCS) uptake among LCS-eligible women undergoing mammography at BJC West County. This evaluation is grounded in the Integrated Screening Action Model that depicts individual- and environmental-level influences on the screening behavior process. Using an explanatory sequential mixed methods design, which combines both quantitative and qualitative approaches, the research questions and specific aims for this proposal are to: a) evaluate the baseline prevalence of LCS among LCS-eligible women; b) assess whether the Pink & Pearl Campaign increases referrals and uptake/ completion of LCS among LCS-eligible women undergoing screening mammography; and c) evaluate individual and environmental factors influencing LCS uptake, and implementation outcomes of the campaign. These implementation outcomes will help identify whether the campaign was put in place successfully or not. This proposal will inform strategies for integrating cancer screening programs to improve poorly performing programs like LCS.
Interventions
None listed
Sponsors
Washington University School of Medicine
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
for Participants: * Undergoing screening mammography * Between the ages of 50-80 years (inclusive) * Reporting a 20 pack-year equivalent of either current smoking history or have quit in the past 15 years * Can speak and understand English * Ability to understand willingness to provide informed consent.
Exclusion criteria
for Participants: * Diagnosed with a serious health problem that will likely limit life expectancy (such as previous history of lung cancer, symptoms of lung cancer such as hemoptysis or unexplained weight loss of more than 6.8 kg (15 lb) in the previous year) * Subjects with symptoms of lung cancer should get a diagnostic CT scan * Unable or unwilling to get treatment if lung cancer is found Eligibility Criteria for Providers: * Older than 20 years of age
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of LCS-eligible women who opt-in to, and successfully, complete LCS mammography and opt-in to lung cancer screening | At baseline | — |
| Number of women screened for LCS | At 3 months | — |
| Feasibility of Pink and Pearl project | At 6 months | Feasibility is defined as the extent to which the strategy is suitable for routine use in a setting. Information on the feasibility of the Pink and Pearl campaign from healthcare providers will be collected using in-depth interviewing. |
| Acceptability of Pink and Pearl project | At 6 months | Acceptability is defined as the perception that the strategy is agreeable or satisfactory. Information on the acceptability of the Pink and Pearl campaign from healthcare providers will be collected using in-depth interviewing. |
| Appropriateness of Pink and Pearl project | At 6 months | Appropriateness is defined as the perceived fit, relevance, or compatibility of the strategy or practice for a given setting. Information on the appropriateness of the Pink and Pearl campaign from healthcare providers will be collected using in-depth interviewing. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Median time to lung cancer screening | Through completion of follow-up (estimated to be 1 year) | — |
| Number of women who have a positive lung radiology screening | Through completion of follow-up (estimated to be 1 year) | — |
| Rate of follow-up for a positive screening examination | Through completion of follow-up (estimated to be 1 year) | — |
| False positive rates | Through completion of follow-up (estimated to be 1 year) | — |
| Invasive intervention rate | Through completion of follow-up (estimated to be 1 year) | Invasive interventions are considered percutaneous cytologic examination or biopsy, bronchoscopy, surgical procedure mediastinoscopy/otmy, and thorascopy/otmy. |
| Cancer yield rate | Through completion of follow-up (estimated to be 1 year) | — |
| Adverse event rate for screening | Through completion of follow-up (estimated to be 1 year) | — |
| Number of women with varying Stage (1-4) findings in the lung screening radiology report. | Through completion of follow-up (estimated to be 1 year) | Histologic type (Bronchioloalveolar carcinoma, adenocarcinoma, squamous-cell carcinoma, large-cell carcinoma, non-small-cell carcinoma or other, small-cell carcinoma, carcinoid). |
| Cause of death | Through completion of follow-up (estimated to be 1 year) | Neoplasm of bronchus and lung, other neoplasm, cardiovascular illness, respiratory illness, complications of medical or surgical care, other. |
Countries
United States
Contacts
CONTACTBeryne Odeny, M.D., MPH, Ph.D.
PRINCIPAL_INVESTIGATORBeryne Odeny, M.D., MPH, Ph.D.
Washington University School of Medicine
Outcome results
None listed