Arthritis, Infectious, Gonococcal (GC) Infection
Conditions
Keywords
gonococcal arthritis
Brief summary
The aim of this retrospective observational study was to describe the epidemiology of Neisseria gonorrhoeae septic arthritis over the last 10 years at Brest and Rennes university hospitals. The main question is whether there are any risk factors based on the epidemiological and clinical data on these cases. The second objective is to characterize the gonococcal strains isolated in order to determine whether there is a common clone, a virulence factor or specific resistance genes.
Interventions
None listed
Sponsors
University Hospital, Brest
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Patients with a Neisseria gonorrhoeae-positive joint sample (from an enrichment vial or a native sample) between 2014 and 2024.
Exclusion criteria
* Patients with Neisseria gonorrhoeae-negative joint sample (from enrichment vial or native sample). * Patients who have expressed opposition to inclusion in the study. * Patients under legal protection (guardianship, curatorship, etc.).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rate of CRP (C-reactive protein) | 10 years | in mg/L |
| Surgery | 10 years | yes or not |
| Evolution | 10 years | recovery or relapse |
| Rate of neutrophils | 10 years | proportion of neutrophils in %. |
| Age | 10 years | years |
| Date of sampling | 10 years | DD/MM/YYYY |
| Type of sample | 10 years | joint fluid or joint fluid on blood culture bottle |
| Rate of white blood cells | 10 years | quantification of white blood cells /mm3 |
| Sexually transmitted infection | 10 years | associated or not, if associated, name of STI and localization |
| Men who have sex with men | 10 years | yes or no |
| HIV pre-exposure prophylaxis (PreP) | 10 years | yes or no |
| Comorbidities | 10 years | any history mentioned in the medical file, such as fracture, illness, treatment, chronic alcoholism, cancer, diabetes, etc. |
| Imaging | 10 years | medical conclusion of the ultrasound or radiology performed |
| Blood cultures (peripheral blood) | 10 years | positive or negative |
| Time to diagnosis | 10 years | in days (between onset of symptoms and antibiotics) |
| Treatments implemented | 10 years | name of the probabilistic treatment (antibiotic) and after identification or antibiogram |
| Antibiotic sensitivity profile | 10 years | Susceptibility or resistance according to SIR methodology and, if achieved: minimum inhibitory concentrations of antibiotics tested on the strain in mg/L |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Molecular typing: virulence factors | 10 years | performed on strains sent to the Centre National de Référence des IST - APHP |
| Molecular typing: resistance genes | 10 years | performed on strains sent to the Centre National de Référence des IST - APHP |
| Molecular typing: clone | 10 years | performed on strains sent to the Centre National de Référence des IST - APHP |
Countries
France
Contacts
Primary ContactGeneviève HERY-ARNAUD
Backup ContactValentin LEMOINE
Outcome results
None listed