Comparison of Permethrin and Ivermectin in Children Greater Than 6 Yrs Age for Treatment of Scabies

Comparison of Topical Permethrin 1 Day Verses 2 Day Application Versus Oral Ivermectin for Treatment of Scabies in Children Greater Than 6 Yrs of Age

Status

Not yet recruiting

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06896929

Acronym

not existed

Enrollment

Registered

2025-03-26

Start date

2025-05-01

Completion date

2026-04-01

Last updated

2025-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Scabies

Keywords

Comparison of permethrin and ivermectin in scabies

Brief summary

Scabies is highly contagious,pruritic infestation of skin.Various treatment modalities have been used but search for ideal scabicide is ongoing.we wnt to coduct this study to compare the outcome of permethrin verses ivermectin in children for treatment of scabies .This randomized clinical trial will be done in children hospital lahore for 12 months.Sample size of 90 cases;30 in each group will be included through non probability consecutive sampling.Then patient will be randomly divided into 3 groups.In group A patient will be given 5% permethrin topical application to whole body single application. In Group B ,patients will be given topical permethrin for twice application 24 hrs appart ,In group C patients will be given Tablet Ivermectin single dose 200microgram/kg.Then patients will be examined after 2 weeks and 4 weeks for no of lesions and pruritis and cure will be labeled.All this information will be recorded on performa .Data will be entered and analysed by using SPSS version 26.Three groups will be compared for cure by using chi-square test.P value less than and equal to 0.05 will be considered as significant.

Interventions

DRUGPermethrin Cream, 5%

Permethrin 5% cream will be given as a single application

DRUGIvermectin 200 µg/kg

Group C will be given Tab Ivermectin

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

6 Years to 15 Years

Healthy volunteers

Inclusion criteria

* Age 6-15 * Both genders * Diagnosed with scabies (as per operational definition)

Exclusion criteria

* Children with recurrent scabies on medical record * Known allergy to ivermectin or permethrin. * Widespread eczema or impetigo. * Liver dysfunction or renal failure

Design outcomes

Primary

Measure	Time frame	Description
Cure of scabies.	12 months	Cure will be labeled if greater han 50% reduction in no of lesions and pruritis observed after 4 weeks of treatment.

Countries

Pakistan

Contacts

Primary ContactSadaf Wazir, MBBs

sadaffahad302@gmail.com97403284231293

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026