Constitutional Thinness
Conditions
Keywords
Constitutional thinness (CT), Adapted Physical Activity, Compensatory nutrition, Lean and muscle mass gain, Resistance to gain weight
Brief summary
Constitutional Thinness (CT) is a form of stable thinness without malnutrition but with resistance to weight gain, affecting approximately 1% of the general population. The clinical consequences are numerous and the pathophysiology remains poorly understood. Currently, conventional management involves a high-calorie and frequent diet, combined with the avoidance of endurance physical activity, although there is no significant evidence of its effectiveness. Our hypothesis is that an adapted physical activity program (APA) combined with compensatory nutrition (CN) could help these patients gain lean mass (muscle mass).
Interventions
The APA intervention will consist of a 2-week running-in period, followed by a period of adapted physical activity (APA) for 8 weeks.
BEHAVIORALCompensatory Nutrition (NC)
The Compensatory Nutrition (NC) intervention will consist of a 2-week running-in period, followed by a period of compensated nutrition (NC) for 8 weeks.
Sponsors
Laboratoire Interuniversitaire de Biologie de la Motricité
Target Tape
Centre Hospitalier Universitaire de Saint Etienne
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* Gender: Female * BMI: ≤ 18.5 kg/m² * Weight Stability: Stable weight for at least 3 months * Age: 18 to 50 years old at the inclusion visit * Diagnosed with Constitutional thinness
Exclusion criteria
* Pregnancy, Parturition, or Lactation * Legal Restrictions: Individuals deprived of liberty, involuntarily hospitalized, or hospitalized for reasons other than research purposes, adults under legal protection (guardianship or curatorship) or unable to provide consent * Eating Disorders: Individuals with eating disorders (DSM IV and 5 criteria) * Excessive Alcohol Consumption: Consumption exceeding the equivalent of 10 glasses of wine per week * Severe Progressive Conditions: Progressive severe conditions (e.g., diabetes) * Intense Physical Activity: Individuals engaging in intense physical activity (\> 3 sessions per week) * Heavy Smoking: Significant smoking (\>10 cigarettes per day) * Psychiatric Conditions: Presence of depressive or psychiatric conditions requiring antidepressant or psychotropic treatment * Medical or Surgical History: Medical or surgical history deemed incompatible with the study by the investigator * MRI Contraindication: Individuals with contraindications to MRI will not undergo spectro-MRI analyses
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Lean body mass | From day 1 to week 8 | Lean body mass gain (kg) measured by bioimpedance |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| BMI | From day 1 to week 8 | Body masse index : ratio between weight and height |
| Energy balance | From day 1 to week 8 | Ratio between calorie intake and calorie expenditure Caloric intake measured by dietary records over 2 weeks (calorie); Calorie expenditure: Resting metabolism measured by indirect calorimetry (kcal/24h); + Postprandial thermogenesis measured by indirect calorimetry (kcal/24h);; + Physical activity energy expenditure measured by connected watch (kcal/24h); |
| Physical exercise capacity | From day 1 to week 8 | Changes in VO2max |
| Quality of life SF-12 questionnaire | From day 1 to week 8 | SF-12 questionnaire; Self-measurement questionnaire SF-12 (Short Form Health Survey 12); comprising 12 questions assessing 8 dimensions, namely physical functioning, role limitation due to physical problems, role limitation resulting from emotional problems, vitality (energy/fatigue), emotional well-being, social functioning, bodily pain, and perception of general and mental health; each dimension is represented by a score ranging from 0 to 100, with a low score signifying poor health perception in the dimension considered, and a high score signifying the opposite); |
Countries
France
Contacts
Primary ContactNatacha GERMAIN, PhD
Backup ContactFlorence RANCON, Cheffe de projet
Outcome results
None listed