Dry Eye, Obesity, PreDiabetes, Psoriasis
Conditions
Brief summary
insulin resistant psoriatic obese patients may complain problems of dryness of eye. Intermittent fasting may improve dryness of eye, obesity, insulin resistance, and psoriasis. Exercise, as applied in pyramidal form, if added to intermittent fasting may improve effect of intermittent fasting.
Detailed description
forty obese patients with dryness of eye, obesity, insulin resistance (prediabetes), and psoriasis (chronic plaque) will randomly distributed to group I (n =20 patients) or group II (n=20). Both groups will receive The intermittent fasting regimen consisted of eating ad libitum for five days and then will restrict calories ('fasting') for two days per week, for a duration of 12 weeks. On the fasting days, participants will be instructed to restrict their calories to a maximum of 600 kcal/day for females and 650 kcal/day for males. The intermittent fasting intervention will consist of a dietary intervention based on the 5:2 fasting diet. Subjects will be asked to consume a total of allowed calories in a window of 6 hours or less from 8:00 am till 2:00 pm, twice per week on 2 non-consecutive days. Group I will receive a pyramidal training will be adopted for nearly 60 minutes (nearly two rounds of 21 minutes of running on electronic treadmill will be separated with 10 minutes of rest between the two rounds. Also, warming (4 minutes before start of pyrimidal trianing) and cooling (4 minutes after pyramidal training) will be done through gentle stretching exercises/activities. the exercise will be applied 3 times weekly for 2 weeks
Interventions
BEHAVIORALpyramidal training plus intermittent fasting
twenty obese patients with dryness of eye, obesity, (prediabetes), and psoriasis will receive intermittent fasting consisted of eating ad libitum for 5 days and then will restrict calories ('fasting') for two days weekly, for 12 weeks. On the fasting days, participants will restrict calories to a maximum of 600 kcal/day for females and 650 kcal/day for males. The dietary intervention will be based on the 5:2 fasting diet. Subjects will be asked to consume a total of allowed calories in a window of 6 hours or less from 8:00 am till 2:00 pm, twice per week on 2 non-consecutive days. also this group will receive a pyramidal training nearly 60 minutes (nearly two rounds of 21 minutes of running on treadmill will be separated with 10 min of rest between the two rounds. Also, warming (4 min before start of pyrimidal trianing) and cooling (4 minu after pyramidal training) will be done through gentle stretching. the exercise will be applied 3 times weekly for 12 weeks
BEHAVIORALintermittent fasting
twenty obese patients with dryness of eye, obesity, (prediabetes), and psoriasis will receive intermittent fasting consisted of eating ad libitum for 5 days and then will restrict calories ('fasting') for two days weekly, for 12 weeks. On the fasting days, participants will restrict calories to a maximum of 600 kcal/day for females and 650 kcal/day for males. The dietary intervention will be based on the 5:2 fasting diet. Subjects will be asked to consume a total of allowed calories in a window of 6 hours or less from 8:00 am till 2:00 pm, twice per week on 2 non-consecutive days.
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
45 Years to 55 Years
Healthy volunteers
No
Inclusion criteria
* chronic plaque psoriasis * obesity class I * prediabetic persons * dryness of both eyes
Exclusion criteria
* cardiac insults * respiratory insults * diabetics hypertensives or renal, hepatic insults
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| schrimer test | it will be assessed after 12 weeks | it is a test for eye dryness |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| System of Dry eye scoring | it will be assessed after 12 weeks | it is a questionnaire for eye dryness assessment |
| Ocular surface disability index | it will be assessed after 12 weeks | it is a questionnaire for eye dryness assessment |
| Dermatology life quality index | it will be assessed after 12 weeks | it is a questionnaire for psoriasis-associated life quality assessment |
| Tear film break-up timing | it will be assessed after 12 weeks | it is a test for eye dryness |
| Fasting serum blood glucose | it will be assessed after 12 weeks | it will measure of blood fasting glucose |
| Waist circumference | it will be assessed after 12 weeks | it will be assessed via tape |
| Body mass index | it will be assessed after 12 weeks | it will be assessed on empty stomach |
| Psoriasis area and severity index | it will be assessed after 12 weeks | A PASI score is a tool used to measure the severity and extent of psoriasis. PASI is an acronym for Psoriasis Area and Severity Index.The PASI is a widely used instrument in psoriasis trials that assesses and grades the severity of psoriatic lesions. PASI combines the assessment of the severity of lesions and the area affected into a single score in the range 0 (no disease) to 72 (maximal disease). |
Countries
Egypt
Contacts
Primary ContactAli MA Isamil, Lecturer
Backup Contacthatem abdelfatah, Lecturer
Outcome results
None listed