Chronic Rhinosinusitis Phenotype With Nasal Polyps (CRSwNP), Smell Loss
Conditions
Keywords
Dupilumab, Chronic Rhinosinusitis with Nasal Polyps, Smell Loss, Electrophysiology
Brief summary
The goal of this observational study is to learn what can predict the return of the sense of smell in patients with chronic rhinosinusitis with nasal polyps being treated with dupilumab. The main questions it aims to answer are: 1. Does obstruction of the olfactory cleft predict return of the sense of smell? 2. Do electrophysiological signals generated by breathing and sniffing behavior predict return of the sense of smell? Participants starting dupilumab will undergo assessment for their degree of olfactory cleft obstruction, and an electrophysiologic assessment of their olfactory cleft and be followed over 6 months of treatment with dupilumab.
Interventions
24 weeks of dupilumab 300mg q2 weeks
Sponsors
Sanofi
Northwestern University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Well documented history of CRSwNP * BSIT age/sex classified as abnormal score * Self-reported stable olfactory deficit of moderate to severe quality \> 3 months * Prior endoscopic sinus surgery \>3 months, \<10 years prior
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Status change of the Brief Smell Identification Test | 26 weeks | The brief smell identification test will be administered and patients classified into normal/age-related deficit vs abnormal. |
Countries
United States
Contacts
Primary ContactClinical Coordinator
Backup ContactBruce Tan, MD
Outcome results
None listed