Parkinson, Parkinson's Disease
Conditions
Keywords
Parkinson's Disease, Ketogenic Diet, Intermittent Fasting, Ketoflex 12/3, Neurodegenerative Disorders
Brief summary
This study aims to investigate the effects of the Ketoflex 12/3 diet on motor and non-motor symptoms in patients with Parkinson's disease. Participants will follow the Ketoflex 12/3 dietary regimen, and their cognitive function, motor symptoms, sleep patterns, gastrointestinal health, and overall well-being will be assessed through standardized clinical scales. The study will help determine whether a plant-based ketogenic diet combined with intermittent fasting can have a beneficial impact on Parkinson's disease progression.
Detailed description
Parkinson's disease is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms. Emerging evidence suggests that dietary interventions, particularly ketogenic diets and intermittent fasting, may play a role in neuroprotection and symptom management. This study investigates the effects of the Ketoflex 12/3 diet, a plant-based ketogenic dietary approach combined with intermittent fasting, on Parkinson's disease progression. Clinical assessments will include Unified Parkinson's Disease Rating Scale (UPDRS), Mini-Mental State Examination (MMSE), depression and anxiety scales, sleep quality assessments, and gastrointestinal health evaluations. The study aims to provide new insights into the potential benefits of metabolic-based nutritional interventions in Parkinson's disease patients.
Interventions
BEHAVIORALKetoflex 12/3 Diet
A plant-based ketogenic diet combined with intermittent fasting (12/3)
Sponsors
Istanbul Medipol University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosed with Parkinson's disease * Age between 40-85 years * Native Turkish speakers * Able to comply with the study protocol
Exclusion criteria
* History of alcohol or substance dependence * Diagnosis of chronic renal failure * Presence of neuromuscular disorders * Having amalgam dental fillings and/or failure to remove them according to the SMART protocol * Severe vitamin deficiencies that have not been corrected prior to the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Motor Symptoms as Measured by the Unified Parkinson's Disease Rating Scale (UPDRS) | Baseline and 6 months | The Unified Parkinson's Disease Rating Scale (UPDRS) is used to evaluate the severity of motor symptoms in Parkinson's disease. Scores range from 0 to 108 for the motor section, with higher scores indicating worse motor impairment. |
Countries
Turkey (Türkiye)
Outcome results
None listed