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Diffusion MRI for Quantitative Assessment of Myofascial Pain

Development of RPBM for Quantitative Assessment of Myofascial Pain

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06892041
Enrollment
90
Registered
2025-03-24
Start date
2025-09-04
Completion date
2026-07-31
Last updated
2025-10-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Masticatory Myofascial Pain Syndrome

Brief summary

The purpose of this study is to assess the diagnostic accuracy of diffusion MRI for evaluation of the jaw muscles for patients with masticatory myofascial pain syndrome.

Interventions

None listed

Sponsors

National Center for Complementary and Integrative Health (NCCIH)
CollaboratorNIH
New York University
CollaboratorOTHER
Weill Medical College of Cornell University
Lead SponsorOTHER

Study design

Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes

Inclusion criteria

* Men and women 18-65 years of age * Ability to give informed consent * Symptoms meeting criteria for normal or latent/active temporomandibular myofascial pain

Exclusion criteria

* Contraindications to MRI scanning including severe obesity or difficulty in laying in a supine position, intracranial clips, metal implants, external metallic devices/objects/clips within 10mm of the head, suspected or confirmed metal in the eyes (history of welding or similar activity), claustrophobia, cardiac pacemaker or pacing wires * Pregnancy or breast feeding * Traumatic injury of masticatory muscles or temporomandibular joint within last 12 months * Mandibular fracture within last 12 months * Initiation of additional treatment of myofascial pain within the past 1 month * Received masseter Botox within the last 4 months

Design outcomes

Primary

MeasureTime frame
Difference in mean diffusion MRI parameters of temporalis and masseter muscles between patients at the normal stage and those at the latent/active pain stage.Day 1

Countries

United States

Contacts

Primary ContactElizabeth Lane
ell2032@med.cornell.edu646-962-8394

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026