Magnesium Level, Wisdom Tooth Removal, Wound Healing
Conditions
Keywords
blood magnesium level, oral surgery, wound healing
Brief summary
The surgical extraction of an impacted tooth is one of the most common procedures in oral surgery. Following extraction, the tissue undergoes repair and regeneration through a process known as socket healing (SH). SH is a complex and highly regulated biological process. Several local, surgical, and systemic factors can influence SH. This study aimed to evaluate the impact of the magnesium depletion score (MDS) on the socket healing following tooth extraction.
Detailed description
The surgical extraction of impacted teeth is one of the most commonly performed procedures in the field of oral surgery. According to the American Dental Association (ADA), surgical extraction involves the removal of a tooth that has either erupted or not into the mouth, which includes the removal of a mucoperiosteal flap and the trimming of a portion of the tooth and/or bone. Complications related to post-extraction wound healing-such as pain, swelling, bleeding, and infection-can pose significant challenges for both patients and surgeons. Optimal healing depends not only on the tissue itself but also on various local, surgical, and systemic factors, including but not limited to the patient's stress levels, oral hygiene, age, sex, overall health status, and nutrition, many of which may be beyond intervention or control. Consequently, there is growing interest in treatments that can enhance wound healing. Recent studies indicate that magnesium consumption may have a beneficial effect on the healing process.
Interventions
None listed
Sponsors
Saglik Bilimleri Universitesi
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* Systemically healthy adult participants who were scheduled to undergo surgical extraction of lower impacted third molars.
Exclusion criteria
* Refusal to consent * Presence of chronic diseases * Use of medications that affect wound healing (steroids, bisphosphonate, or immunosuppressives) * Prior radiotherapy in the head and neck area * Pregnancy * Inability to self-evaluate, and inability to communicate verbally or in writing.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Magnesium depletion score (MDS) | 6 weeks | The MDS is calculated by aggregating four factors: 1. Diuretic use: Current use of diuretics is assigned 1 point. 2. PPI use: Current use of proton pump inhibitors (PPIs) is assigned 1 point. 3. Kidney function: * If the estimated glomerular filtration rate (eGFR) is between 60 and 90 mL/(min · 1.73 m²), 1 point is assigned. * If the eGFR is less than 60 mL/(min · 1.73 m²), 2 points are assigned. The total MDS score ranges from 0 to 4, based on the accumulation of points from these factors. |
| Assessment of Wound healing (WH) | 6 weeks | Wound Healing (WH) will be assessed by using a scale called Inflammatory Proliferative Remodeling (IPR) Scale. According to the scale, each phase of WH is scored based on the parameters, including edema, bleeding and swelling. The total score of the IPR scale ranges from 0 to 16; 0-4 indicates poor healing; 5-10, acceptable healing; and 11-16, excellent healing. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Post-operative pain | 3 days | Post-operative pain will be assessed using the Visual Analog Scale (VAS). Patients will be asked to rate their pain on a scale from 0 to 10, where 0 indicates no pain and 10 represents the worst imaginable pain. |
Countries
Turkey (Türkiye)
Outcome results
None listed