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Studio TIARA: Alessitimia ed Emicrania Cronica

Studio TIARA: Alessitimia ed Emicrania Cronica

Status
Enrolling by invitation
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06891053
Acronym
TIARA
Enrollment
350
Registered
2025-03-24
Start date
2022-05-30
Completion date
2025-12-31
Last updated
2025-10-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alexithymia, Migraine

Brief summary

The aim of this observational, cross-sectional study is to investigate the relationship between alexithymia and migraine frequency (considering alexithymia a condition that can influence the severity of the clinical phenotype of migraine, favoring its chronicization), in an analysis adjusted for psychiatric comorbidity (for anxiety and depression, potentially influencing migraine chronicization) and for personalogical factor represented by apathy.

Interventions

None listed

Sponsors

Azienda Sanitaria Locale di Alessandria
Lead SponsorOTHER

Study design

Observational model
OTHER
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
FEMALE
Age
12 Years to 65 Years
Healthy volunteers
No

Inclusion criteria

* Diagnosis of episodic migraine with or without aura, chronic migraine and/or MOH according to ICHD-3 2018 criteria; * Patients aged 12-65 years; * Female patients

Exclusion criteria

* Ongoing major depressive episode; * Comorbidities for major internal diseases (hepatopathy, nephropathy, heart failure, etc.); * Alcohol or substance abuse disorder (eoin, cocaine, cannabis, hallucinogens); * Language barrier; * Low cultural/cognitive level; * No informed consent.

Design outcomes

Primary

MeasureTime frameDescription
Degree of alexithymiaIn 3 periods of 30 days each (3 months), which make up the 90-day observation time intervalIndependent variable measured as a score on the TAS-20 scale
Migraine frequencyIn 3 periods of 30 days each (3 months), which make up the 90-day observation time interval

Secondary

MeasureTime frame
Number of drug days in patients diagnosed with MOHIn 3 periods of 30 days each (3 months), which make up the 90-day observation time interval
Degree of alessithymia in patients diagnosed with MOHIn 3 periods of 30 days each (3 months), which make up the 90-day observation time interval

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026