Hepatitis D Virus Infection
Conditions
Keywords
HDV
Brief summary
This is a territory-wide cross-sectional study of all individuals living with HIV/HBV coinfection and HBV-related HCC.
Detailed description
Chronic hepatitis B virus (HBV) infection remains endemic in Hong Kong with an estimated prevalence of 6.2% in the recent Population Health Survey 2020-2022.1 The estimated prevalence of chronic HBV infection among individuals living with HIV is 8%.2 Yet, no data are available concerning the disease burden of hepatitis delta virus (HDV) among individuals living with HIV/HBV coinfection.
Interventions
None listed
Sponsors
Gilead Sciences
Grace Lai Hung Wong
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Individuals with HIV infection, i.e. anti-HIV or HIV RNA positive; AND 2. Individuals with chronic hepatitis B, i.e. hepatitis B surface antigen (HBsAg) or HBV DNA positive for two times at least 6 months apart; AND 3. Aged 18 years old or above. 4. Written or verbal consent obtained
Exclusion criteria
1. Refusal to consent 2. Age \< 18 years
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rate of positive anti-HDV | at screening | Primary endpoint is seroprevalence rate of positive anti-HDV |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence rate of detectable HDV RNA | at screening | Prevalence rate of detectable HDV RNA |
| Prevalence rate of compensated advanced chronic liver disease | at screening | Prevalence rate of compensated advanced chronic liver disease (cACLD) defined as a liver stiffness measurement above 10.0 kPa |
Countries
Hong Kong
Contacts
Primary ContactAngel Chim
Outcome results
None listed