Thalassemia
Conditions
Brief summary
Recent advances in the management of thalassemia have significantly improved life expectancy and quality of life of patients with this hemoglobinopathy, with a consequent increase in their reproductive potential and desire to have children.Since an initial report of a successful pregnancy in a woman with thalassemia major by Walker in 1969, hundreds of pregnancies have been reported so far, highlighting that women carefully managed in the preconception phase usually carry out a successful gestation and labor, both in case of spontaneous conception and assisted reproductive techniques.
Interventions
None listed
Sponsors
Fondazione per la Ricerca sulle Anemie ed Emoglobinopatie in Italia
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Transfusion dependent and nontransfusion- dependent thalassemia * Pregnancy ended with the birth of a live or dead foetus * Pregnancy ended in miscarriage or voluntary abortion * Pregnancy in progress
Exclusion criteria
* Other types of anemia * Pregnancy not initiated despite assisted fertilization practices * Subjects unwilling to sign informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| foetal death | 15 YEARS | To evaluate foetal death |
| number of pregnancies in women with beta thalassemia followed in Italian centres | 15 YEARS | To evaluate the number of pregnancies in women with beta thalassemia followed in Italian centres and how the increase in the average age of the thalassemia population impact on the number of new pregnancies over time |
| number of pregnancies spontaneously | 15 YEARS | many pregnancies occurred spontaneously |
| number of pregnancies after hormonal stimulation | 15 YEARS | number of pregnancies after hormonal stimulation |
| likelihood of miscarriage | 15 YEARS | To evaluate the likelihood of miscarriage |
Countries
Italy
Outcome results
None listed