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Comparative Study Between Oxytocin Infusion Before and After Placental Delivery on Blood Loss During and After Cesarean Delivery .

Comparative Study Between Oxytocin Infusion Before and After Placental Delivery on Blood Loss During and After Cesarean Delivery in Low Risk Women.

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06889155
Enrollment
64
Registered
2025-03-21
Start date
2023-08-30
Completion date
2024-09-14
Last updated
2025-03-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intraoperative Blood Loss

Brief summary

Participants were randomized using computer-generated random numbers into 2 groups. Group I included 32 women who received oxytocin infusion before placental delivery just after cord clamping and group II included 32 women who received oxytocin infusion after placental delivery. In both groups 10 IU of oxytocin (Syntocinon, Novartis, Basel, Switzerland) were diluted in 500 mL of normal saline and administered through intravenous infusion over 30 minutes.

Detailed description

Participants were randomized using computer-generated random numbers into 2 groups. Group I included 32 women who received oxytocin infusion before placental delivery just after cord clamping and group II included 32 women who received oxytocin infusion after placental delivery. In both groups 10 IU of oxytocin (Syntocinon, Novartis, Basel, Switzerland) were diluted in 500 mL of normal saline and administered through intravenous infusion over 30 minutes.

Interventions

DRUGOxytocin

10 IU of oxytocin (Syntocinon, Novartis, Basel, Switzerland) were diluted in 500 mL of normal saline and administered through intravenous infusion over 30 minutes.

Sponsors

Cairo University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
No

Inclusion criteria

* Age 18 - 40 years * singleton full term pregnancy. * Candidate for elective cesarean delivery under spinal anaesthesia

Exclusion criteria

* women at high risk for intraoperative bleeding as those with placenta previa or other placental abnormalities * women with bleeding or coagulation disorders. * Medical disorder associating pregnancy as preeclampsia or diabetes * Allergy or contraindications to oxytocin * Fetal macrosomia, or congenital anomalies * Polyhydramnios * Uterine abnormalities as fibroids * Women with intraoperative complications as vascular or visceral injuries

Design outcomes

Primary

MeasureTime frameDescription
Intraoperative blood lossduring cesarean deliveryThis was measured by weighing the surgical sponges and the suction canisters used during the procedure

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026