VExUS Score and AKI in Critically Ill Adult patients-a Prospective Observational Study.

Correlation of Point of Care Venous Excess Ultrasonography (VExUS) Score and Acute Kidney Injury (AKI) in Critically Ill Adult Patients- a Prospective Observational Study.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06889116

Enrollment

Registered

2025-03-21

Start date

2023-05-15

Completion date

2024-01-11

Last updated

2025-03-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Kidney Injury, VExUS

Keywords

VExUS, Acute Kidney Injury, Cumulative fluid balance, Point of Care Ultrasound

Brief summary

Introduction Renal perfusion is dependent on the renal perfusion pressure across the renal capillaries. Venous congestion due to excess fluid therapy can drastically reduce the renal perfusion pressure in spite of a normal mean arterial pressure. Increasing cumulative fluid balance during the ICU stay has been found to be associated with negative outcomes including acute kidney injury (AKI) and hospital mortality. Venous excess ultrasound (VExUS) to assess the Doppler studies of renal, hepatic and portal veins along with the inferior venacava has been shown to reliably predict the incidence of AKI in certain ICU patient population more specifically in cardiorenal syndrome. The aim of this study was to correlate the incidence of AKI and VExUS scores in a mixed ICU population and hence determine the contribution of venous congestion on the causation of AKI in a general ICU. Methods: The patients included who have AKI at admission or developed AKI during their ICU stay were included. The definition of AKI used for this study was as defined by Kidney Disease: Improving Global Outcomes (KDIGO). Point of care VExUS scans were done on each patient at inclusion (day 0), then each day for a total of 4 days (day 1, 2 and 3), till initiation of renal replacement therapy, death or discharge form the ICU. Correlation between VExUS grades and creatinine clearances was explored as the primary objective.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age ≥18 years * Admitted to the adult ICUs of TUTH (ICU A and ICU B) * Admitting diagnosis of AKI or who developed AKI during their ICU stay

Exclusion criteria

* Pregnancy * Diagnosed case of chronic kidney disease * Diagnosed case of cirrhosis/ portal hypertension * Arrhythmias which would interfere with the acquisition and interpretation of the Doppler waveforms * Inferior venacava thrombus * Poor window for assessment

Design outcomes

Primary

Measure	Time frame
To determine correlation between the VExUS score with creatinine clearance.	At the end of Day 3 or initiation of renal replacement therapy or resolution of AKI, death or discharge from the ICU. whichever came first.

Countries

Nepal

Outcome results