Dilated Perivascular Spaces in the Dentate Nucleus on MRI in Patients With Hypertensive Angiopathy or Cerebral Amyloid Angiopathy

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06888882

Acronym

HA-DN-DPVS

Enrollment

Registered

2025-03-21

Start date

2025-04-01

Completion date

2025-12-31

Last updated

2026-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebral Amyloid Angiopathy, Hypertensive Arteriopathy

Brief summary

Hypertensive arteriopathy (HA) and cerebral amyloid angiopathy (CAA) are the two most common forms of cerebral small vessel disease. On MRI, chronic small vessel disease-related abnormalities include white matter hyperintensities, dilated perivascular spaces (DPVS), lacunar infarction, and hemorrhagic features (e.g. cerebral microbleeds, CMB). In the cerebellum, deep CMB involving the dentate nucleus (DN) is associated with HA, whereas the presence of superficial cerebellar CMB are associated with CAA. DPVS are observed in both diseases, predominant in the subcortical white matter (especially in the centrum semiovale) in CAA whereas HA-related DPVS are predominant deep in the brain inside or nearby the basal ganglia. To the best of our knowledge, DN-DPVS have never been studies systematically in small vessel disease. The researchers want to study DN-DPVS on T2-weighted 3T MRI in patients with HA or CAA and to compare both groups.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patient registered in the CHU de Nîmes (France) stroke database with lobar intracerebral hemorrhage \[ICH\], subarachnoid hemorrhage or cortical superficial siderosis for CAA or basal ganglion ICH for HA * Patient managed at the CHU de Nîmes (France) between 01/1/2015 and 31/12/2024 * Patient with T2-weighted MRI performed with a 3T magnet

Exclusion criteria

* Refusal to participate

Design outcomes

Primary

Measure	Time frame	Description
Sex	baseline	Comparaison of both populations (HA/CAA), H/F
Hypertension	baseline	history of hypertension (Yes/No)
Age	baseline	Age at time of T2-weighted imaging,
Time	baseline	Time between initial MRI-based CAA/HA diagnosis and 3T T2-weighted imaging, axial or coronal views of T2 imaging,
MRI view	baseline	T2 performed using coronal or axial imaging (axial / coronal
hypercholesterolemia	baseline	history of hypercholesterolemia (Yes/No)
Hemorrhagic lesion	baseline	Hemorrhagic lesion load on T2\*-weighted imaging (ICH and CMB for both CAA and HA, and subarachnoid hemorrhage/cortical superficial siderosis for CAA)
Subcortical lobar DPVS	baseline	Semi-quantitative score for evaluation of subcortical lobar DPVS (0 if DPVS are absent, 1 if 1 to 10 DPVS are visible, 2 for 11 to 20 DPVS, 3 for 21 to 40 DPVS, and 4 for \>40 DPVS).
DPVS of basal ganglia	baseline	Semi-quantitative score for evaluation of DPVS of basal ganglia (0 if DPVS are absent, 1 if 1 to 10 DPVS are visible, 2 for 11 to 20 DPVS, 3 for 21 to 40 DPVS, and 4 for \>40 DPVS).
Diabete	baseline	history of diabetes (Yes/No)
Smoking	Baseline	current smoking (Yes / No)

Countries

France

Contacts

STUDY_DIRECTORAnissa MEGZARI

Centre Hospitalier Universitaire de Nīmes

Outcome results