Drug Addiction
Conditions
Keywords
heroin, advanced social cognitive function
Brief summary
This project aims to explore key brain functional and biochemical indicators associated with impaired advanced social cognition through an integrated approach encompassing unconscious control, conscious control, cognitive flexibility, problem-solving, and social interaction domains. By incorporating multimodal measures spanning physiological, neural, cognitive, psychological, and behavioral dimensions, we will develop a comprehensive intervention protocol combining course-based brain stimulation and cognitive training. The study will employ a multi-timepoint, multi-level assessment framework to track the enhancement of higher cognitive functions and brain functional recovery in individuals undergoing drug rehabilitation.
Interventions
DEVICETranscranial direct current stimulation
The participant cohort recruited for this study consists of individuals with substance use disorder (SUD), specifically those addicted to drugs. During the intervention phase, this group will adhere to a strict non-pharmacological intervention protocol, meaning they will not receive any form of pharmacotherapy, neurosurgical intervention, or other neuromodulation-based cognitive interventions, including but not limited to techniques such as transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS). This design aims to ensure the internal validity of the study results and to exclude potential confounding effects of other interventions on neuroplasticity and cognitive function.
Sponsors
Nanyang Technological University
Shaanxi Normal University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
30 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* age between 30 and 60 years; * fulfilling the diagnostic criteria for severe substance use disorder as specified in the Fifth Edition of the Diagnostic and Statistical Manual of Mental Disorders. * a history of heroin use exceeding ten years, with a daily average intake of at least 0.1 grams. * abstinence duration of eight months or less, with a positive result of a urine test before entering the rehabilitation center. * no history of neuromodulation treatments such as tDCS within the past six months.
Exclusion criteria
* a history of alcohol dependence, neurological disorders, or other complex psychiatric conditions. * the presence of intracranial metallic implants or elevated intracranial pressure. * a history of epilepsy or recent electroencephalogram evidence of epileptiform activity. * the use of implanted electronic devices, such as pacemakers;. * scalp hyperalgesia or a tendency toward bleeding. * severe cardiac conditions.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Realistic presented problem task score | From enrollment to the end of treatment at 1 month | Used to measure problem-solving ability |
| Scores on the pattern game task | From enrollment to the end of treatment at 1 month | Used to measure social cooperation and competition |
| Score on the Group Realistic Problem Solving task | From enrollment to the end of treatment at 1 month | Used to measure collaborative problem-solving ability |
| Cortical activation from fNIRS | From enrollment to the end of treatment at 1 month | — |
| Cortical functional connectivity from fNIRS | From enrollment to the end of treatment at 1 month | — |
| Inter-brain neural synchronization from fNIRS hyperscaning | From enrollment to the end of treatment at 1 month | — |
| EEG power | From enrollment to the end of treatment at 1 month | — |
| EEG microstate | From enrollment to the end of treatment at 1 month | — |
| Functional connectivity from EEG | From enrollment to the end of treatment at 1 month | — |
| Score on the joint drawing task | From enrollment to the end of treatment at 1 month | Used to measure interactive collaboration. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Average fixation duration from eye-traking | From enrollment to the end of treatment at 1 month | — |
| Fixation time percentage from eye-traking | From enrollment to the end of treatment at 1 month | — |
| Alternative use task (AUT) score | From enrollment to the end of treatment at 1 month | Used to measure problem-solving ability |
| Score on the Group Alternative Use Task | From enrollment to the end of treatment at 1 month | Used to measure collaborative problem solving ability |
| Cognitive flexibility | From enrollment to the end of treatment at 1 month | Assessed by Wisconsin Card Quest (WCST). |
| Cognitive inhibition | From enrollment to the end of treatment at 1 month | Assessed by stroop task |
| Mind wandering | From enrollment to the end of treatment at 1 month | Assessed by interpolation task |
| Pupil response from eye-tracking | From enrollment to the end of treatment at 1 month | — |
Countries
China
Outcome results
None listed